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Why must T cells be cross-reactive?
Clonal selection theory proposed that individual T cells are specific for a single peptide–MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast array of potential foreign peptide–MHC complexes, and a comprehensive system requires each T cell to recognize numerous...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097784/ https://www.ncbi.nlm.nih.gov/pubmed/22918468 http://dx.doi.org/10.1038/nri3279 |