Cargando…

Peptide Combination Generator: a Tool for Generating Peptide Combinations

[Image: see text] Peptides are used as reagents both for basic research and diagnostic purposes. Therefore, there is a need for novel methods for the design of peptide molecules with a particular specific physiochemical profile. The properties of the peptides are governed by the nature of amino acid...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Naseem, Shamoon, Arzoo, Yadav, Neelesh, Sharma, Tanuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097909/
https://www.ncbi.nlm.nih.gov/pubmed/32226857
http://dx.doi.org/10.1021/acsomega.9b03848
Descripción
Sumario:[Image: see text] Peptides are used as reagents both for basic research and diagnostic purposes. Therefore, there is a need for novel methods for the design of peptide molecules with a particular specific physiochemical profile. The properties of the peptides are governed by the nature of amino acids constituting the peptide. There is a lack of a web server or tools which could predict all the possible combinations of the peptides generated because of the combinations of amino acids based on the physiochemical properties. We have developed a peptide combination generator (PepCoGen), a web server for generating all the possible combinations of peptides by varying the amino acids having similar physiochemical properties at a particular position. It also predicts other properties of the peptides including molecular weight, charge, solubility, hydrophobic plot, and isoelectric point, and random three-dimensional models for each generated combination.