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Peptide Combination Generator: a Tool for Generating Peptide Combinations
[Image: see text] Peptides are used as reagents both for basic research and diagnostic purposes. Therefore, there is a need for novel methods for the design of peptide molecules with a particular specific physiochemical profile. The properties of the peptides are governed by the nature of amino acid...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097909/ https://www.ncbi.nlm.nih.gov/pubmed/32226857 http://dx.doi.org/10.1021/acsomega.9b03848 |
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author | Ali, Naseem Shamoon, Arzoo Yadav, Neelesh Sharma, Tanuj |
author_facet | Ali, Naseem Shamoon, Arzoo Yadav, Neelesh Sharma, Tanuj |
author_sort | Ali, Naseem |
collection | PubMed |
description | [Image: see text] Peptides are used as reagents both for basic research and diagnostic purposes. Therefore, there is a need for novel methods for the design of peptide molecules with a particular specific physiochemical profile. The properties of the peptides are governed by the nature of amino acids constituting the peptide. There is a lack of a web server or tools which could predict all the possible combinations of the peptides generated because of the combinations of amino acids based on the physiochemical properties. We have developed a peptide combination generator (PepCoGen), a web server for generating all the possible combinations of peptides by varying the amino acids having similar physiochemical properties at a particular position. It also predicts other properties of the peptides including molecular weight, charge, solubility, hydrophobic plot, and isoelectric point, and random three-dimensional models for each generated combination. |
format | Online Article Text |
id | pubmed-7097909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70979092020-03-27 Peptide Combination Generator: a Tool for Generating Peptide Combinations Ali, Naseem Shamoon, Arzoo Yadav, Neelesh Sharma, Tanuj ACS Omega [Image: see text] Peptides are used as reagents both for basic research and diagnostic purposes. Therefore, there is a need for novel methods for the design of peptide molecules with a particular specific physiochemical profile. The properties of the peptides are governed by the nature of amino acids constituting the peptide. There is a lack of a web server or tools which could predict all the possible combinations of the peptides generated because of the combinations of amino acids based on the physiochemical properties. We have developed a peptide combination generator (PepCoGen), a web server for generating all the possible combinations of peptides by varying the amino acids having similar physiochemical properties at a particular position. It also predicts other properties of the peptides including molecular weight, charge, solubility, hydrophobic plot, and isoelectric point, and random three-dimensional models for each generated combination. American Chemical Society 2020-03-16 /pmc/articles/PMC7097909/ /pubmed/32226857 http://dx.doi.org/10.1021/acsomega.9b03848 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Ali, Naseem Shamoon, Arzoo Yadav, Neelesh Sharma, Tanuj Peptide Combination Generator: a Tool for Generating Peptide Combinations |
title | Peptide Combination Generator: a Tool for Generating
Peptide Combinations |
title_full | Peptide Combination Generator: a Tool for Generating
Peptide Combinations |
title_fullStr | Peptide Combination Generator: a Tool for Generating
Peptide Combinations |
title_full_unstemmed | Peptide Combination Generator: a Tool for Generating
Peptide Combinations |
title_short | Peptide Combination Generator: a Tool for Generating
Peptide Combinations |
title_sort | peptide combination generator: a tool for generating
peptide combinations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097909/ https://www.ncbi.nlm.nih.gov/pubmed/32226857 http://dx.doi.org/10.1021/acsomega.9b03848 |
work_keys_str_mv | AT alinaseem peptidecombinationgeneratoratoolforgeneratingpeptidecombinations AT shamoonarzoo peptidecombinationgeneratoratoolforgeneratingpeptidecombinations AT yadavneelesh peptidecombinationgeneratoratoolforgeneratingpeptidecombinations AT sharmatanuj peptidecombinationgeneratoratoolforgeneratingpeptidecombinations |