Cargando…
Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
The microenvironment of solid tumors plays an essential role in tumor progression. In lung cancer, the stromal cells produce a fibronectin rich extracellular matrix which is known to contribute to both tumor metastasis and drug resistance. Due to its conformational lability, fibronectin is considera...
Autores principales: | Cho, Christina, Horzempa, Carol, Longo, Christine M., Peters, Donna M., Jones, David M., McKeown-Longo, Paula J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097952/ https://www.ncbi.nlm.nih.gov/pubmed/32231714 http://dx.doi.org/10.7150/jca.39771 |
Ejemplares similares
-
The First Type III Domain of Fibronectin is Associated with the Expression of Cytokines within the Lung Tumor Microenvironment
por: Zheng, Mingzhe, et al.
Publicado: (2011) -
The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells
por: Cho, Christina, et al.
Publicado: (2016) -
Regulation of the Innate Immune Response by Fibronectin: Synergism between the III-1 and EDA Domains
por: Kelsh, Rhiannon, et al.
Publicado: (2014) -
Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin
por: Zheng, Mingzhe, et al.
Publicado: (2020) -
Induction of pro-inflammatory genes by fibronectin DAMPs in three fibroblast cell lines: Role of TAK1 and MAP kinases
por: Maddali, Pranav, et al.
Publicado: (2023)