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Strategic Trastuzumab Mediated Crosslinking Driving Concomitant HER2 and HER3 Endocytosis and Degradation in Breast Cancer

Efficacious anticancer therapies for targeting plasma membrane receptors with antibody based therapeutics are often contingent on sufficient endocytic delivery of receptor and conjugate to lysosomes. This results in downregulation of receptor activity and, in the case of antibody-drug conjugates (AD...

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Detalles Bibliográficos
Autores principales:	Wymant, Jennifer Mary, Sayers, Edward John, Muir, Duncan, Jones, Arwyn Tomos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097966/ https://www.ncbi.nlm.nih.gov/pubmed/32231734 http://dx.doi.org/10.7150/jca.32470

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