Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K

[Image: see text] A precise determination method of azilsartan solubility between 293.15 and 333.15 K in several ordinary solvents and some of their aqueous mixtures was established by high-performance liquid chromatography. In all tested solvents, its solubility shows exponential growth with the in...

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Autores principales: Xu, Haojie, Kang, Lingling, Qin, Jinmei, Lin, Jiayu, Xue, Min, Meng, Zihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097992/
https://www.ncbi.nlm.nih.gov/pubmed/32226897
http://dx.doi.org/10.1021/acsomega.0c00156
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author Xu, Haojie
Kang, Lingling
Qin, Jinmei
Lin, Jiayu
Xue, Min
Meng, Zihui
author_facet Xu, Haojie
Kang, Lingling
Qin, Jinmei
Lin, Jiayu
Xue, Min
Meng, Zihui
author_sort Xu, Haojie
collection PubMed
description [Image: see text] A precise determination method of azilsartan solubility between 293.15 and 333.15 K in several ordinary solvents and some of their aqueous mixtures was established by high-performance liquid chromatography. In all tested solvents, its solubility shows exponential growth with the increase in temperature. This trend is especially pronounced in methanol and ethanol. The order of solubility of azilsartan can be expressed as ethanol > tetrahydrofuran > ethanol/water (8/2, v/v) > methanol > methanol/water (8/2, v/v) > n-propanol > isopropanol > ethanol/Water (5/5, v/v) > acetonitrile. The solubility data of azilsartan were well correlated by the λh model. Moreover, the thermodynamic data including the dissolving enthalpy, entropy, and Gibbs free energy of azilsartan in each solvent were calculated which is crucial to its preparation technology study.
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spelling pubmed-70979922020-03-27 Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K Xu, Haojie Kang, Lingling Qin, Jinmei Lin, Jiayu Xue, Min Meng, Zihui ACS Omega [Image: see text] A precise determination method of azilsartan solubility between 293.15 and 333.15 K in several ordinary solvents and some of their aqueous mixtures was established by high-performance liquid chromatography. In all tested solvents, its solubility shows exponential growth with the increase in temperature. This trend is especially pronounced in methanol and ethanol. The order of solubility of azilsartan can be expressed as ethanol > tetrahydrofuran > ethanol/water (8/2, v/v) > methanol > methanol/water (8/2, v/v) > n-propanol > isopropanol > ethanol/Water (5/5, v/v) > acetonitrile. The solubility data of azilsartan were well correlated by the λh model. Moreover, the thermodynamic data including the dissolving enthalpy, entropy, and Gibbs free energy of azilsartan in each solvent were calculated which is crucial to its preparation technology study. American Chemical Society 2020-03-13 /pmc/articles/PMC7097992/ /pubmed/32226897 http://dx.doi.org/10.1021/acsomega.0c00156 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Xu, Haojie
Kang, Lingling
Qin, Jinmei
Lin, Jiayu
Xue, Min
Meng, Zihui
Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title_full Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title_fullStr Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title_full_unstemmed Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title_short Solubility of Azilsartan in Methanol, Ethanol, Acetonitrile, n-Propanol, Isopropanol, Tetrahydrofuran, and Binary Solvent Mixtures between 293.15 and 333.15 K
title_sort solubility of azilsartan in methanol, ethanol, acetonitrile, n-propanol, isopropanol, tetrahydrofuran, and binary solvent mixtures between 293.15 and 333.15 k
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097992/
https://www.ncbi.nlm.nih.gov/pubmed/32226897
http://dx.doi.org/10.1021/acsomega.0c00156
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