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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View
The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remai...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098063/ https://www.ncbi.nlm.nih.gov/pubmed/32101723 http://dx.doi.org/10.1016/j.trecan.2020.01.004 |
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| author | Xavier, Joao B. Young, Vincent B. Skufca, Joseph Ginty, Fiona Testerman, Traci Pearson, Alexander T. Macklin, Paul Mitchell, Amir Shmulevich, Ilya Xie, Lei Caporaso, J. Gregory Crandall, Keith A. Simone, Nicole L. Godoy-Vitorino, Filipa Griffin, Timothy J. Whiteson, Katrine L. Gustafson, Heather H. Slade, Daniel J. Schmidt, Thomas M. Walther-Antonio, Marina R.S. Korem, Tal Webb-Robertson, Bobbie-Jo M. Styczynski, Mark P. Johnson, W. Evan Jobin, Christian Ridlon, Jason M. Koh, Andrew Y. Yu, Michael Kelly, Libusha Wargo, Jennifer A. |
| author_facet | Xavier, Joao B. Young, Vincent B. Skufca, Joseph Ginty, Fiona Testerman, Traci Pearson, Alexander T. Macklin, Paul Mitchell, Amir Shmulevich, Ilya Xie, Lei Caporaso, J. Gregory Crandall, Keith A. Simone, Nicole L. Godoy-Vitorino, Filipa Griffin, Timothy J. Whiteson, Katrine L. Gustafson, Heather H. Slade, Daniel J. Schmidt, Thomas M. Walther-Antonio, Marina R.S. Korem, Tal Webb-Robertson, Bobbie-Jo M. Styczynski, Mark P. Johnson, W. Evan Jobin, Christian Ridlon, Jason M. Koh, Andrew Y. Yu, Michael Kelly, Libusha Wargo, Jennifer A. |
| author_sort | Xavier, Joao B. |
| collection | PubMed |
| description | The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach. |
| format | Online Article Text |
| id | pubmed-7098063 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70980632021-03-01 The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View Xavier, Joao B. Young, Vincent B. Skufca, Joseph Ginty, Fiona Testerman, Traci Pearson, Alexander T. Macklin, Paul Mitchell, Amir Shmulevich, Ilya Xie, Lei Caporaso, J. Gregory Crandall, Keith A. Simone, Nicole L. Godoy-Vitorino, Filipa Griffin, Timothy J. Whiteson, Katrine L. Gustafson, Heather H. Slade, Daniel J. Schmidt, Thomas M. Walther-Antonio, Marina R.S. Korem, Tal Webb-Robertson, Bobbie-Jo M. Styczynski, Mark P. Johnson, W. Evan Jobin, Christian Ridlon, Jason M. Koh, Andrew Y. Yu, Michael Kelly, Libusha Wargo, Jennifer A. Trends Cancer Article The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach. 2020-02-07 2020-03 /pmc/articles/PMC7098063/ /pubmed/32101723 http://dx.doi.org/10.1016/j.trecan.2020.01.004 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Xavier, Joao B. Young, Vincent B. Skufca, Joseph Ginty, Fiona Testerman, Traci Pearson, Alexander T. Macklin, Paul Mitchell, Amir Shmulevich, Ilya Xie, Lei Caporaso, J. Gregory Crandall, Keith A. Simone, Nicole L. Godoy-Vitorino, Filipa Griffin, Timothy J. Whiteson, Katrine L. Gustafson, Heather H. Slade, Daniel J. Schmidt, Thomas M. Walther-Antonio, Marina R.S. Korem, Tal Webb-Robertson, Bobbie-Jo M. Styczynski, Mark P. Johnson, W. Evan Jobin, Christian Ridlon, Jason M. Koh, Andrew Y. Yu, Michael Kelly, Libusha Wargo, Jennifer A. The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title | The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title_full | The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title_fullStr | The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title_full_unstemmed | The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title_short | The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View |
| title_sort | cancer microbiome: distinguishing direct and indirect effects requires a systemic view |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098063/ https://www.ncbi.nlm.nih.gov/pubmed/32101723 http://dx.doi.org/10.1016/j.trecan.2020.01.004 |
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