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Mending a broken heart: current strategies and limitations of cell-based therapy

The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the lost cardiomyocytes, the crux of the matter i...

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Autores principales: Liew, Lee Chuen, Ho, Beatrice Xuan, Soh, Boon-Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098097/
https://www.ncbi.nlm.nih.gov/pubmed/32216837
http://dx.doi.org/10.1186/s13287-020-01648-0
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author Liew, Lee Chuen
Ho, Beatrice Xuan
Soh, Boon-Seng
author_facet Liew, Lee Chuen
Ho, Beatrice Xuan
Soh, Boon-Seng
author_sort Liew, Lee Chuen
collection PubMed
description The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the lost cardiomyocytes, the crux of the matter in ischemic heart disease, with pluripotent stem cell-derived cardiomyocytes (PSC-CM) has been validated with promising pre-clinical results. Nevertheless, clinical translation was hemmed in by limitations such as immature cardiac properties, long-term engraftment, graft-associated arrhythmias, immunogenicity, and risk of tumorigenicity. The continuous progress of stem cell-based cardiac therapy, incorporated with tissue engineering strategies and delivery of cardio-protective exosomes, provides an optimistic outlook on the development of curative treatment for heart failure. This review provides an overview and current status of stem cell-based therapy for heart regeneration, with particular focus on the use of PSC-CM. In addition, we also highlight the associated challenges in clinical application and discuss the potential strategies in developing successful cardiac-regenerative therapy.
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spelling pubmed-70980972020-03-27 Mending a broken heart: current strategies and limitations of cell-based therapy Liew, Lee Chuen Ho, Beatrice Xuan Soh, Boon-Seng Stem Cell Res Ther Review The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the lost cardiomyocytes, the crux of the matter in ischemic heart disease, with pluripotent stem cell-derived cardiomyocytes (PSC-CM) has been validated with promising pre-clinical results. Nevertheless, clinical translation was hemmed in by limitations such as immature cardiac properties, long-term engraftment, graft-associated arrhythmias, immunogenicity, and risk of tumorigenicity. The continuous progress of stem cell-based cardiac therapy, incorporated with tissue engineering strategies and delivery of cardio-protective exosomes, provides an optimistic outlook on the development of curative treatment for heart failure. This review provides an overview and current status of stem cell-based therapy for heart regeneration, with particular focus on the use of PSC-CM. In addition, we also highlight the associated challenges in clinical application and discuss the potential strategies in developing successful cardiac-regenerative therapy. BioMed Central 2020-03-26 /pmc/articles/PMC7098097/ /pubmed/32216837 http://dx.doi.org/10.1186/s13287-020-01648-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liew, Lee Chuen
Ho, Beatrice Xuan
Soh, Boon-Seng
Mending a broken heart: current strategies and limitations of cell-based therapy
title Mending a broken heart: current strategies and limitations of cell-based therapy
title_full Mending a broken heart: current strategies and limitations of cell-based therapy
title_fullStr Mending a broken heart: current strategies and limitations of cell-based therapy
title_full_unstemmed Mending a broken heart: current strategies and limitations of cell-based therapy
title_short Mending a broken heart: current strategies and limitations of cell-based therapy
title_sort mending a broken heart: current strategies and limitations of cell-based therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098097/
https://www.ncbi.nlm.nih.gov/pubmed/32216837
http://dx.doi.org/10.1186/s13287-020-01648-0
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