Attenuation of RNA viruses by redirecting their evolution in sequence space

RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their evolutionary potential. We rationally altered the genomes of Coxs...

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Detalles Bibliográficos
Autores principales: Moratorio, Gonzalo, Henningsson, Rasmus, Barbezange, Cyril, Carrau, Lucia, Bordería, Antonio V., Blanc, Hervé, Beaucourt, Stephanie, Poirier, Enzo Z., Vallet, Thomas, Boussier, Jeremy, Mounce, Bryan C., Fontes, Magnus, Vignuzzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098180/
https://www.ncbi.nlm.nih.gov/pubmed/28581455
http://dx.doi.org/10.1038/nmicrobiol.2017.88

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