Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents

BACKGROUND: Faster off-rate competitive enzyme inhibitors are generally more sensitive than slower off-rate ones to binding inhibition by enzyme substrates. We previously reported that the cyclic adenosine monophosphate concentration in dopamine D(1) receptor-expressing medium spiny neurons (D(1)-MS...

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Detalles Bibliográficos
Autores principales: Harada, Akina, Kaushal, Nidhi, Suzuki, Kazunori, Nakatani, Atsushi, Bobkov, Konstantin, Vekich, John A, Doyle, Joseph P, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098246/
https://www.ncbi.nlm.nih.gov/pubmed/31689714
http://dx.doi.org/10.1093/ijnp/pyz056

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