Amiodarone-Induced Acute Liver Injury

Amiodarone is a lipophilic structure with a half-life of 25–100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and r...

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Detalles Bibliográficos
Autores principales: Essrani, Rajesh, Mehershahi, Shehriyar, Essrani, Rajesh Kumar, Ravi, Shri Jai Kirshan, Bhura, Sajeer, Sudhakaran, Anuraj, Hossain, Muhammad, Mehmood, Asif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098330/
https://www.ncbi.nlm.nih.gov/pubmed/32231507
http://dx.doi.org/10.1159/000506184
Descripción
Sumario:Amiodarone is a lipophilic structure with a half-life of 25–100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and rarely acute hepatitis. This is a compelling case of a 60-year-old male who developed acute liver injury 24–36 h after starting amiodarone. All the possible causes of acute liver injury were ruled out, and his liver enzymes improved after discontinuing amiodarone.

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