Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis

Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they can induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case of CMV enterocolitis during steroid therapy for an...

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Detalles Bibliográficos
Autores principales: Furuta, Yoki, Miyamoto, Hideaki, Naoe, Hideaki, Shimoda, Miki, Hinokuma, Yukari, Miyamura, Tomohiro, Miyashita, Azusa, Fukushima, Satoshi, Tanaka, Motohiko, Sasaki, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098339/
https://www.ncbi.nlm.nih.gov/pubmed/32231510
http://dx.doi.org/10.1159/000506186
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author Furuta, Yoki
Miyamoto, Hideaki
Naoe, Hideaki
Shimoda, Miki
Hinokuma, Yukari
Miyamura, Tomohiro
Miyashita, Azusa
Fukushima, Satoshi
Tanaka, Motohiko
Sasaki, Yutaka
author_facet Furuta, Yoki
Miyamoto, Hideaki
Naoe, Hideaki
Shimoda, Miki
Hinokuma, Yukari
Miyamura, Tomohiro
Miyashita, Azusa
Fukushima, Satoshi
Tanaka, Motohiko
Sasaki, Yutaka
author_sort Furuta, Yoki
collection PubMed
description Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they can induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case of CMV enterocolitis during steroid therapy for an irAE. A 77-year-old man with unresectable malignant melanoma was treated with ipilimumab. He suffered from immune-related colitis (irColitis) and was treated with methylprednisolone. Although corticosteroids initially improved his symptoms, CMV reactivation occurred and colitis was exacerbated. Antiviral therapy improved his symptoms without augmenting the immunosuppressive therapy. CMV colitis should be considered when a patient with irColitis shows resistance to immunosuppressive therapy.
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spelling pubmed-70983392020-03-30 Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis Furuta, Yoki Miyamoto, Hideaki Naoe, Hideaki Shimoda, Miki Hinokuma, Yukari Miyamura, Tomohiro Miyashita, Azusa Fukushima, Satoshi Tanaka, Motohiko Sasaki, Yutaka Case Rep Gastroenterol Single Case Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they can induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case of CMV enterocolitis during steroid therapy for an irAE. A 77-year-old man with unresectable malignant melanoma was treated with ipilimumab. He suffered from immune-related colitis (irColitis) and was treated with methylprednisolone. Although corticosteroids initially improved his symptoms, CMV reactivation occurred and colitis was exacerbated. Antiviral therapy improved his symptoms without augmenting the immunosuppressive therapy. CMV colitis should be considered when a patient with irColitis shows resistance to immunosuppressive therapy. S. Karger AG 2020-02-25 /pmc/articles/PMC7098339/ /pubmed/32231510 http://dx.doi.org/10.1159/000506186 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Furuta, Yoki
Miyamoto, Hideaki
Naoe, Hideaki
Shimoda, Miki
Hinokuma, Yukari
Miyamura, Tomohiro
Miyashita, Azusa
Fukushima, Satoshi
Tanaka, Motohiko
Sasaki, Yutaka
Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title_full Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title_fullStr Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title_full_unstemmed Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title_short Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis
title_sort cytomegalovirus enterocolitis in a patient with refractory immune-related colitis
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098339/
https://www.ncbi.nlm.nih.gov/pubmed/32231510
http://dx.doi.org/10.1159/000506186
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