Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

OBJECTIVE: STAP1, encoding for STAP1 (signal transducing adaptor family member 1), has been reported as a candidate gene associated with familial hypercholesterolemia. Unlike established familial hypercholesterolemia genes, expression of STAP1 is absent in liver but mainly observed in immune cells....

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Detalles Bibliográficos
Autores principales: Loaiza, Natalia, Hartgers, Merel L., Reeskamp, Laurens F., Balder, Jan-Willem, Rimbert, Antoine, Bazioti, Venetia, Wolters, Justina C., Winkelmeijer, Maaike, Jansen, Hans P.G., Dallinga-Thie, Geesje M., Volta, Andrea, Huijkman, Nicolette, Smit, Marieke, Kloosterhuis, Niels, Koster, Mirjam, Svendsen, Arthur F., van de Sluis, Bart, Hovingh, G. Kees, Grefhorst, Aldo, Kuivenhoven, Jan Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Translational Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098433/
https://www.ncbi.nlm.nih.gov/pubmed/31996024
http://dx.doi.org/10.1161/ATVBAHA.119.313470

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