Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice

Previously, we showed that peripheral administration of 2-ME (2-methoxyestradiol), a CYP1B1 (cytochrome P450 1B1)-catechol-O-methyltransferase (COMT) generated metabolite of E2 (17β-Estradiol), protects against angiotensin II-induced hypertension in female mice. The demonstration that central E2 inh...

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Detalles Bibliográficos
Autores principales: Singh, Purnima, Song, Chi Young, Dutta, Shubha Ranjan, Gonzalez, Frank J., Malik, Kafait U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098446/
https://www.ncbi.nlm.nih.gov/pubmed/32148125
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098446/
https://www.ncbi.nlm.nih.gov/pubmed/32148125
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14548

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