Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

The ubiquitin ligase Parkin, protein kinase PINK1, USP30 deubiquitylase, and p97 segregase function together to regulate turnover of damaged mitochondria via mitophagy, but our mechanistic understanding in neurons is limited. Here, we combine induced neurons (iNeurons) derived from embryonic stem ce...

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Detalles Bibliográficos
Autores principales: Ordureau, Alban, Paulo, Joao A., Zhang, Jiuchun, An, Heeseon, Swatek, Kirby N., Cannon, Joe R., Wan, Qiaoqiao, Komander, David, Harper, J. Wade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098486/
https://www.ncbi.nlm.nih.gov/pubmed/32142685
http://dx.doi.org/10.1016/j.molcel.2019.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098486/
https://www.ncbi.nlm.nih.gov/pubmed/32142685
http://dx.doi.org/10.1016/j.molcel.2019.11.013

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