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Preregistration of exploratory research: Learning from the golden age of discovery

Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inad...

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Detalles Bibliográficos
Autor principal: Dirnagl, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098547/
https://www.ncbi.nlm.nih.gov/pubmed/32214315
http://dx.doi.org/10.1371/journal.pbio.3000690
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author Dirnagl, Ulrich
author_facet Dirnagl, Ulrich
author_sort Dirnagl, Ulrich
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description Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful.
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spelling pubmed-70985472020-04-03 Preregistration of exploratory research: Learning from the golden age of discovery Dirnagl, Ulrich PLoS Biol Perspective Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful. Public Library of Science 2020-03-26 /pmc/articles/PMC7098547/ /pubmed/32214315 http://dx.doi.org/10.1371/journal.pbio.3000690 Text en © 2020 Ulrich Dirnagl http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective
Dirnagl, Ulrich
Preregistration of exploratory research: Learning from the golden age of discovery
title Preregistration of exploratory research: Learning from the golden age of discovery
title_full Preregistration of exploratory research: Learning from the golden age of discovery
title_fullStr Preregistration of exploratory research: Learning from the golden age of discovery
title_full_unstemmed Preregistration of exploratory research: Learning from the golden age of discovery
title_short Preregistration of exploratory research: Learning from the golden age of discovery
title_sort preregistration of exploratory research: learning from the golden age of discovery
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098547/
https://www.ncbi.nlm.nih.gov/pubmed/32214315
http://dx.doi.org/10.1371/journal.pbio.3000690
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