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Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Aldehyde dehydrogenases (ALDHs) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in ALDH1A1, ALDH1A3, or ALDH3A1, 86% of which were gene...

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Detalles Bibliográficos
Autores principales:	Rebollido-Rios, Rocio, Venton, Geoffroy, Sánchez-Redondo, Sara, Iglesias i Felip, Carmela, Fournet, Guy, González, Elena, Romero Fernández, Wilber, Borroto Escuela, Dasiel Oscar, Di Stefano, Barbara, Penarroche-Díaz, Reinier, Martin, Guillaume, Ceylan, Ismail, Costello, Regis, Perez-Alea, Mileidys
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098886/ https://www.ncbi.nlm.nih.gov/pubmed/32015486 http://dx.doi.org/10.1038/s41388-020-1184-9

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