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A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint
Osteoarthritis affects the morphological properties of the femoral head. The goal of this study was to develop a method to elucidate whether these changes are localised to discrete regions, or if the reported trends in microstructural changes may be identified throughout the subchondral bone of the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098981/ https://www.ncbi.nlm.nih.gov/pubmed/32218496 http://dx.doi.org/10.1038/s41598-020-62614-7 |
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author | Ryan, M. Barnett, L. Rochester, J. Wilkinson, J. M. Dall’Ara, E. |
author_facet | Ryan, M. Barnett, L. Rochester, J. Wilkinson, J. M. Dall’Ara, E. |
author_sort | Ryan, M. |
collection | PubMed |
description | Osteoarthritis affects the morphological properties of the femoral head. The goal of this study was to develop a method to elucidate whether these changes are localised to discrete regions, or if the reported trends in microstructural changes may be identified throughout the subchondral bone of the human femoral head. Whole femoral heads extracted from osteoarthritic (n = 5) and healthy controls (n = 5) underwent microCT imaging 39 μm voxel size. The subchondral bone plate was virtually isolated to evaluate the plate thickness and plate porosity. The trabecular bone region was divided into 37 volumes of interest spatially distributed in the femoral head, and bone morphometric properties were determined in each region. The study showed how the developed approach can be used to study the heterogeneous properties of the human femoral head affected by a disease such as osteoarthritis. As example, in the superior femoral head osteoarthritic specimens exhibited a more heterogeneous micro-architecture, with trends towards thicker cortical bone plate, higher trabecular connectivity density, higher trabecular bone density and thicker structures, something that could only be observed with the newly developed approach. Bone cysts were mostly confined to the postero-lateral quadrants extending from the subchondral region into the mid trabecular region. Nevertheless, in order to generalise these findings, a larger sample size should be analysed in the future. This novel method allowed a comprehensive evaluation of the heterogeneous micro-architectural properties of the human femoral head, highlighting effects of OA in the superior subchondral cortical and trabecular bone. Further investigations on different stages of OA would be needed to identify early changes in the bone. |
format | Online Article Text |
id | pubmed-7098981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70989812020-03-30 A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint Ryan, M. Barnett, L. Rochester, J. Wilkinson, J. M. Dall’Ara, E. Sci Rep Article Osteoarthritis affects the morphological properties of the femoral head. The goal of this study was to develop a method to elucidate whether these changes are localised to discrete regions, or if the reported trends in microstructural changes may be identified throughout the subchondral bone of the human femoral head. Whole femoral heads extracted from osteoarthritic (n = 5) and healthy controls (n = 5) underwent microCT imaging 39 μm voxel size. The subchondral bone plate was virtually isolated to evaluate the plate thickness and plate porosity. The trabecular bone region was divided into 37 volumes of interest spatially distributed in the femoral head, and bone morphometric properties were determined in each region. The study showed how the developed approach can be used to study the heterogeneous properties of the human femoral head affected by a disease such as osteoarthritis. As example, in the superior femoral head osteoarthritic specimens exhibited a more heterogeneous micro-architecture, with trends towards thicker cortical bone plate, higher trabecular connectivity density, higher trabecular bone density and thicker structures, something that could only be observed with the newly developed approach. Bone cysts were mostly confined to the postero-lateral quadrants extending from the subchondral region into the mid trabecular region. Nevertheless, in order to generalise these findings, a larger sample size should be analysed in the future. This novel method allowed a comprehensive evaluation of the heterogeneous micro-architectural properties of the human femoral head, highlighting effects of OA in the superior subchondral cortical and trabecular bone. Further investigations on different stages of OA would be needed to identify early changes in the bone. Nature Publishing Group UK 2020-03-26 /pmc/articles/PMC7098981/ /pubmed/32218496 http://dx.doi.org/10.1038/s41598-020-62614-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ryan, M. Barnett, L. Rochester, J. Wilkinson, J. M. Dall’Ara, E. A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title | A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title_full | A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title_fullStr | A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title_full_unstemmed | A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title_short | A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
title_sort | new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098981/ https://www.ncbi.nlm.nih.gov/pubmed/32218496 http://dx.doi.org/10.1038/s41598-020-62614-7 |
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