In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG(+ve) B Cells

B cells are critical for promoting autoimmunity and the success of B cell depletion therapy in rheumatoid arthritis (RA) confirms their importance in driving chronic inflammation. Whilst disease specific autoantibodies are useful diagnostically, our understanding of the pathogenic B cell repertoire...

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Detalles Bibliográficos
Autores principales: Cowan, Graeme J. M., Miles, Katherine, Capitani, Lorenzo, Giguere, Sophie S. B., Johnsson, Hanna, Goodyear, Carl, McInnes, Iain B., Breusch, Steffen, Gray, David, Gray, Mohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099054/
https://www.ncbi.nlm.nih.gov/pubmed/32265907
http://dx.doi.org/10.3389/fimmu.2020.00395

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