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Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

Picornavirus replication is critically dependent on the correct processing of a polyprotein precursor by 3C protease(s) (3C(pro)) at multiple specific sites with related but non-identical sequences. To investigate the structural basis of its cleavage specificity, we performed the first crystallograp...

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Detalles Bibliográficos
Autores principales:	Zunszain, Patricia A., Knox, Stephen R., Sweeney, Trevor R., Yang, Jingjie, Roqué-Rosell, Núria, Belsham, Graham J., Leatherbarrow, Robin J., Curry, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099390/ https://www.ncbi.nlm.nih.gov/pubmed/19883658 http://dx.doi.org/10.1016/j.jmb.2009.10.048

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