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Computational Design of an Allosteric Antibody Switch by Deletion and Rescue of a Complex Structural Constellation
[Image: see text] Therapeutic monoclonal antibodies have transformed medicine, especially with regards to treating cancers and disorders of the immune system. More than 50 antibody-derived drugs have already reached the clinic, the majority of which target cytokines or cell-surface receptors. Unfort...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099597/ https://www.ncbi.nlm.nih.gov/pubmed/32232139 http://dx.doi.org/10.1021/acscentsci.9b01065 |