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Development and validation of an HILIC–MS/MS method by one-step precipitation for chloroquine in miniature pig plasma

BACKGROUND: Quantification of polar compounds such as chloroquine by revered-phase LC is a challenge because of poor retention and silanol interactions with stationary phase. Strong ion-pairing reagents added to mobile phases to improve reversed-phase retention and improve peak shape can be harmful...

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Detalles Bibliográficos
Autores principales:	Wang, Zhan-Zhang, Lu, Hao-Yang, Shang, De-Wei, Ni, Xiao-Jia, Zhang, Ming, Wen, Yu-Guan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Science Ltd 2016
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099630/ https://www.ncbi.nlm.nih.gov/pubmed/27211608 http://dx.doi.org/10.4155/bio-2015-0032

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