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Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis

Diabetes mellitus (DM) is a chronic inflammatory disease, and the rapidly increasing DM is becoming a major problem of global public health. Traditional Chinese medicine (TCM) has a long history of treating diabetes. It has been developed and utilized because of its good efficacy and no toxic side e...

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Autores principales: Ge, Qi, Chen, Liang, Yuan, Yi, Liu, Lanlan, Feng, Fan, Lv, Peng, Ma, Shangshang, Chen, Keping, Yao, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099657/
https://www.ncbi.nlm.nih.gov/pubmed/32265717
http://dx.doi.org/10.3389/fphar.2020.00347
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author Ge, Qi
Chen, Liang
Yuan, Yi
Liu, Lanlan
Feng, Fan
Lv, Peng
Ma, Shangshang
Chen, Keping
Yao, Qin
author_facet Ge, Qi
Chen, Liang
Yuan, Yi
Liu, Lanlan
Feng, Fan
Lv, Peng
Ma, Shangshang
Chen, Keping
Yao, Qin
author_sort Ge, Qi
collection PubMed
description Diabetes mellitus (DM) is a chronic inflammatory disease, and the rapidly increasing DM is becoming a major problem of global public health. Traditional Chinese medicine (TCM) has a long history of treating diabetes. It has been developed and utilized because of its good efficacy and no toxic side effects. Lobelia chinensis is a traditional whole grass herbal. With the continuous deepening of pharmacological research on TCM, the active ingredients of L. chinensis are continuously revealed, which contained the alkaloids, flavonoids, flavonoid glycosides and amino acids that have the good effects of anti-inflammatory, anti-viral and anti-diabetic. In order to further explore the targets of active ingredients and its anti-diabetic mechanism, a feasible network pharmacology analysis model based on chemical, pharmacokinetic and pharmacological data was developed by network construction method to clarify the anti-diabetic mechanism of L. chinensis. The present study conducted by gas chromatography–mass spectrometer (GC/MS), which identified 208 metabolites of L. chinensis, of which 23 ingredients may have effective pharmacological effects after absorption, distribution, metabolism, and excretion (ADME) screening. Network pharmacological analysis on the active ingredients revealed that 5-hydroxymethylfurfural in L. chinensis affects the insulin resistance signaling pathway by acting on GSK3B, TNF, and MAPK1, acacetin affects the diabetic pathway by acting on INSR, DPP4, and GSK3B, that regulate type 2 diabetes, non-insulin-dependent DM, and inflammatory diseases. These results successfully indicated the potential anti-diabetic mechanism of the active ingredients of L. chinensis.
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spelling pubmed-70996572020-04-07 Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis Ge, Qi Chen, Liang Yuan, Yi Liu, Lanlan Feng, Fan Lv, Peng Ma, Shangshang Chen, Keping Yao, Qin Front Pharmacol Pharmacology Diabetes mellitus (DM) is a chronic inflammatory disease, and the rapidly increasing DM is becoming a major problem of global public health. Traditional Chinese medicine (TCM) has a long history of treating diabetes. It has been developed and utilized because of its good efficacy and no toxic side effects. Lobelia chinensis is a traditional whole grass herbal. With the continuous deepening of pharmacological research on TCM, the active ingredients of L. chinensis are continuously revealed, which contained the alkaloids, flavonoids, flavonoid glycosides and amino acids that have the good effects of anti-inflammatory, anti-viral and anti-diabetic. In order to further explore the targets of active ingredients and its anti-diabetic mechanism, a feasible network pharmacology analysis model based on chemical, pharmacokinetic and pharmacological data was developed by network construction method to clarify the anti-diabetic mechanism of L. chinensis. The present study conducted by gas chromatography–mass spectrometer (GC/MS), which identified 208 metabolites of L. chinensis, of which 23 ingredients may have effective pharmacological effects after absorption, distribution, metabolism, and excretion (ADME) screening. Network pharmacological analysis on the active ingredients revealed that 5-hydroxymethylfurfural in L. chinensis affects the insulin resistance signaling pathway by acting on GSK3B, TNF, and MAPK1, acacetin affects the diabetic pathway by acting on INSR, DPP4, and GSK3B, that regulate type 2 diabetes, non-insulin-dependent DM, and inflammatory diseases. These results successfully indicated the potential anti-diabetic mechanism of the active ingredients of L. chinensis. Frontiers Media S.A. 2020-03-20 /pmc/articles/PMC7099657/ /pubmed/32265717 http://dx.doi.org/10.3389/fphar.2020.00347 Text en Copyright © 2020 Ge, Chen, Yuan, Liu, Feng, Lv, Ma, Chen and Yao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ge, Qi
Chen, Liang
Yuan, Yi
Liu, Lanlan
Feng, Fan
Lv, Peng
Ma, Shangshang
Chen, Keping
Yao, Qin
Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title_full Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title_fullStr Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title_full_unstemmed Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title_short Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis
title_sort network pharmacology-based dissection of the anti-diabetic mechanism of lobelia chinensis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099657/
https://www.ncbi.nlm.nih.gov/pubmed/32265717
http://dx.doi.org/10.3389/fphar.2020.00347
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