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Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response

In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties...

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Detalles Bibliográficos
Autores principales: Wang, Jianpeng, Teng, Zhidong, Miao, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099752/
https://www.ncbi.nlm.nih.gov/pubmed/32226448
http://dx.doi.org/10.1186/s13662-016-0862-y
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author Wang, Jianpeng
Teng, Zhidong
Miao, Hui
author_facet Wang, Jianpeng
Teng, Zhidong
Miao, Hui
author_sort Wang, Jianpeng
collection PubMed
description In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties on the positivity and boundedness of solutions and the existence of the virus-free, the no-immune, and the infected equilibria are established. By using the Lyapunov functions and linearization methods, the global stability of the equilibria for the model is established. That is, when [Formula: see text] then the virus-free equilibrium is globally asymptotically stable, and under the additional assumption [Formula: see text] when [Formula: see text] and [Formula: see text] then the no-immune equilibrium is globally asymptotically stable and when [Formula: see text] and [Formula: see text] then the infected equilibrium is globally asymptotically stable. Furthermore, the numerical simulations show that even if assumption [Formula: see text] does not hold, the no-immune equilibrium and the infected equilibrium also may be globally asymptotically stable.
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spelling pubmed-70997522020-03-27 Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response Wang, Jianpeng Teng, Zhidong Miao, Hui Adv Differ Equ Research In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties on the positivity and boundedness of solutions and the existence of the virus-free, the no-immune, and the infected equilibria are established. By using the Lyapunov functions and linearization methods, the global stability of the equilibria for the model is established. That is, when [Formula: see text] then the virus-free equilibrium is globally asymptotically stable, and under the additional assumption [Formula: see text] when [Formula: see text] and [Formula: see text] then the no-immune equilibrium is globally asymptotically stable and when [Formula: see text] and [Formula: see text] then the infected equilibrium is globally asymptotically stable. Furthermore, the numerical simulations show that even if assumption [Formula: see text] does not hold, the no-immune equilibrium and the infected equilibrium also may be globally asymptotically stable. Springer International Publishing 2016-05-23 2016 /pmc/articles/PMC7099752/ /pubmed/32226448 http://dx.doi.org/10.1186/s13662-016-0862-y Text en © Wang et al. 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Wang, Jianpeng
Teng, Zhidong
Miao, Hui
Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title_full Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title_fullStr Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title_full_unstemmed Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title_short Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
title_sort global dynamics for discrete-time analog of viral infection model with nonlinear incidence and ctl immune response
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099752/
https://www.ncbi.nlm.nih.gov/pubmed/32226448
http://dx.doi.org/10.1186/s13662-016-0862-y
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