Cargando…
Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response
In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099752/ https://www.ncbi.nlm.nih.gov/pubmed/32226448 http://dx.doi.org/10.1186/s13662-016-0862-y |
_version_ | 1783511359206457344 |
---|---|
author | Wang, Jianpeng Teng, Zhidong Miao, Hui |
author_facet | Wang, Jianpeng Teng, Zhidong Miao, Hui |
author_sort | Wang, Jianpeng |
collection | PubMed |
description | In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties on the positivity and boundedness of solutions and the existence of the virus-free, the no-immune, and the infected equilibria are established. By using the Lyapunov functions and linearization methods, the global stability of the equilibria for the model is established. That is, when [Formula: see text] then the virus-free equilibrium is globally asymptotically stable, and under the additional assumption [Formula: see text] when [Formula: see text] and [Formula: see text] then the no-immune equilibrium is globally asymptotically stable and when [Formula: see text] and [Formula: see text] then the infected equilibrium is globally asymptotically stable. Furthermore, the numerical simulations show that even if assumption [Formula: see text] does not hold, the no-immune equilibrium and the infected equilibrium also may be globally asymptotically stable. |
format | Online Article Text |
id | pubmed-7099752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-70997522020-03-27 Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response Wang, Jianpeng Teng, Zhidong Miao, Hui Adv Differ Equ Research In this paper, a discrete-time analog of a viral infection model with nonlinear incidence and CTL immune response is established by using the Micken non-standard finite difference scheme. The two basic reproduction numbers [Formula: see text] and [Formula: see text] are defined. The basic properties on the positivity and boundedness of solutions and the existence of the virus-free, the no-immune, and the infected equilibria are established. By using the Lyapunov functions and linearization methods, the global stability of the equilibria for the model is established. That is, when [Formula: see text] then the virus-free equilibrium is globally asymptotically stable, and under the additional assumption [Formula: see text] when [Formula: see text] and [Formula: see text] then the no-immune equilibrium is globally asymptotically stable and when [Formula: see text] and [Formula: see text] then the infected equilibrium is globally asymptotically stable. Furthermore, the numerical simulations show that even if assumption [Formula: see text] does not hold, the no-immune equilibrium and the infected equilibrium also may be globally asymptotically stable. Springer International Publishing 2016-05-23 2016 /pmc/articles/PMC7099752/ /pubmed/32226448 http://dx.doi.org/10.1186/s13662-016-0862-y Text en © Wang et al. 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Wang, Jianpeng Teng, Zhidong Miao, Hui Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title | Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title_full | Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title_fullStr | Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title_full_unstemmed | Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title_short | Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response |
title_sort | global dynamics for discrete-time analog of viral infection model with nonlinear incidence and ctl immune response |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099752/ https://www.ncbi.nlm.nih.gov/pubmed/32226448 http://dx.doi.org/10.1186/s13662-016-0862-y |
work_keys_str_mv | AT wangjianpeng globaldynamicsfordiscretetimeanalogofviralinfectionmodelwithnonlinearincidenceandctlimmuneresponse AT tengzhidong globaldynamicsfordiscretetimeanalogofviralinfectionmodelwithnonlinearincidenceandctlimmuneresponse AT miaohui globaldynamicsfordiscretetimeanalogofviralinfectionmodelwithnonlinearincidenceandctlimmuneresponse |