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Clinical implications of recurrent gene mutations in acute myeloid leukemia

Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy characterized by recurrent gene mutations. Genomic heterogeneity, patients’ individual variability, and recurrent gene mutations are the major obstacles among many factors that impact treatment efficacy of the AML patients...

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Autores principales: Yu, Jifeng, Li, Yingmei, Zhang, Danfeng, Wan, Dingming, Jiang, Zhongxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099827/
https://www.ncbi.nlm.nih.gov/pubmed/32231866
http://dx.doi.org/10.1186/s40164-020-00161-7
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author Yu, Jifeng
Li, Yingmei
Zhang, Danfeng
Wan, Dingming
Jiang, Zhongxing
author_facet Yu, Jifeng
Li, Yingmei
Zhang, Danfeng
Wan, Dingming
Jiang, Zhongxing
author_sort Yu, Jifeng
collection PubMed
description Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy characterized by recurrent gene mutations. Genomic heterogeneity, patients’ individual variability, and recurrent gene mutations are the major obstacles among many factors that impact treatment efficacy of the AML patients. With the application of cost- and time-effective next-generation sequencing (NGS) technologies, an enormous diversity of genetic mutations has been identified. The recurrent gene mutations and their important roles in acute myeloid leukemia (AML) pathogenesis have been studied extensively. In this review, we summarize the recent development on the gene mutation in patients with AML.
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spelling pubmed-70998272020-03-30 Clinical implications of recurrent gene mutations in acute myeloid leukemia Yu, Jifeng Li, Yingmei Zhang, Danfeng Wan, Dingming Jiang, Zhongxing Exp Hematol Oncol Review Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy characterized by recurrent gene mutations. Genomic heterogeneity, patients’ individual variability, and recurrent gene mutations are the major obstacles among many factors that impact treatment efficacy of the AML patients. With the application of cost- and time-effective next-generation sequencing (NGS) technologies, an enormous diversity of genetic mutations has been identified. The recurrent gene mutations and their important roles in acute myeloid leukemia (AML) pathogenesis have been studied extensively. In this review, we summarize the recent development on the gene mutation in patients with AML. BioMed Central 2020-03-27 /pmc/articles/PMC7099827/ /pubmed/32231866 http://dx.doi.org/10.1186/s40164-020-00161-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yu, Jifeng
Li, Yingmei
Zhang, Danfeng
Wan, Dingming
Jiang, Zhongxing
Clinical implications of recurrent gene mutations in acute myeloid leukemia
title Clinical implications of recurrent gene mutations in acute myeloid leukemia
title_full Clinical implications of recurrent gene mutations in acute myeloid leukemia
title_fullStr Clinical implications of recurrent gene mutations in acute myeloid leukemia
title_full_unstemmed Clinical implications of recurrent gene mutations in acute myeloid leukemia
title_short Clinical implications of recurrent gene mutations in acute myeloid leukemia
title_sort clinical implications of recurrent gene mutations in acute myeloid leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099827/
https://www.ncbi.nlm.nih.gov/pubmed/32231866
http://dx.doi.org/10.1186/s40164-020-00161-7
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