A comprehensive analysis of methods for assessing polygenic burden on Alzheimer’s disease pathology and risk beyond APOE

Genome-wide association studies have identified dozens of loci that alter the risk to develop Alzheimer’s disease. However, with the exception of the APOE-ε4 allele, most variants bear only little individual effect and have, therefore, limited diagnostic and prognostic value. Polygenic risk scores a...

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Detalles Bibliográficos
Autores principales: Altmann, Andre, Scelsi, Marzia A, Shoai, Maryam, de Silva, Eric, Aksman, Leon M, Cash, David M, Hardy, John, Schott, Jonathan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100005/
https://www.ncbi.nlm.nih.gov/pubmed/32226939
http://dx.doi.org/10.1093/braincomms/fcz047

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