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Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased

PURPOSE OF REVIEW: This review summarizes the current understanding of virus attenuation by large-scale recoding of viral genomes and discusses what would ultimately be necessary for construction of better and safer live modified virus vaccines. RECENT FINDINGS: It has been shown that codon and codo...

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Detalles Bibliográficos
Autores principales:	Osterrieder, Nikolaus, Kunec, Dusan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Recent Developments in Anti-viral Vaccines (K Kousoulas and P Rider, Section Editors)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100164/ https://www.ncbi.nlm.nih.gov/pubmed/32226716 http://dx.doi.org/10.1007/s40588-018-0080-3

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