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Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit

OBJECTIVE: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. STUDY DESIGN: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for tes...

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Autores principales: Poole, Claudette L., Camins, Bernard C., Prichard, Mark N., Faye-Petersen, Ona, Hutto, Cecelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100243/
https://www.ncbi.nlm.nih.gov/pubmed/30723275
http://dx.doi.org/10.1038/s41372-019-0318-9
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author Poole, Claudette L.
Camins, Bernard C.
Prichard, Mark N.
Faye-Petersen, Ona
Hutto, Cecelia
author_facet Poole, Claudette L.
Camins, Bernard C.
Prichard, Mark N.
Faye-Petersen, Ona
Hutto, Cecelia
author_sort Poole, Claudette L.
collection PubMed
description OBJECTIVE: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. STUDY DESIGN: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. RESULTS: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. CONCLUSION: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.
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spelling pubmed-71002432020-03-27 Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit Poole, Claudette L. Camins, Bernard C. Prichard, Mark N. Faye-Petersen, Ona Hutto, Cecelia J Perinatol Article OBJECTIVE: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. STUDY DESIGN: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. RESULTS: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. CONCLUSION: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes. Nature Publishing Group US 2019-02-05 2019 /pmc/articles/PMC7100243/ /pubmed/30723275 http://dx.doi.org/10.1038/s41372-019-0318-9 Text en © Springer Nature America, Inc. 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Poole, Claudette L.
Camins, Bernard C.
Prichard, Mark N.
Faye-Petersen, Ona
Hutto, Cecelia
Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title_full Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title_fullStr Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title_full_unstemmed Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title_short Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
title_sort hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100243/
https://www.ncbi.nlm.nih.gov/pubmed/30723275
http://dx.doi.org/10.1038/s41372-019-0318-9
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