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Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018

Background: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018. Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (...

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Autores principales: Czogała, Małgorzata, Pawińska-Wa̧sikowska, Katarzyna, Ksia̧żek, Teofila, Sikorska-Fic, Barbara, Matysiak, Michał, Rodziewicz-Konarska, Anna, Chybicka, Alicja, Skalska-Sadowska, Jolanta, Wachowiak, Jacek, Muszyńska-Rosłan, Katarzyna, Krawczuk-Rybak, Maryna, Grabowski, Dominik, Kowalczyk, Jerzy, Zielezińska, Karolina, Urasiński, Tomasz, Tomaszewska, Renata, Szczepański, Tomasz, Karpińska-Derda, Irena, Woszczyk, Mariola, Pohorecka, Joanna, Karolczyk, Grażyna, Młynarski, Wojciech, Mycko, Katarzyna, Badowska, Wanda, Skoczeń, Szymon, Balwierz, Walentyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100382/
https://www.ncbi.nlm.nih.gov/pubmed/32266181
http://dx.doi.org/10.3389/fped.2020.00086
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author Czogała, Małgorzata
Pawińska-Wa̧sikowska, Katarzyna
Ksia̧żek, Teofila
Sikorska-Fic, Barbara
Matysiak, Michał
Rodziewicz-Konarska, Anna
Chybicka, Alicja
Skalska-Sadowska, Jolanta
Wachowiak, Jacek
Muszyńska-Rosłan, Katarzyna
Krawczuk-Rybak, Maryna
Grabowski, Dominik
Kowalczyk, Jerzy
Zielezińska, Karolina
Urasiński, Tomasz
Tomaszewska, Renata
Szczepański, Tomasz
Karpińska-Derda, Irena
Woszczyk, Mariola
Pohorecka, Joanna
Karolczyk, Grażyna
Młynarski, Wojciech
Mycko, Katarzyna
Badowska, Wanda
Skoczeń, Szymon
Balwierz, Walentyna
author_facet Czogała, Małgorzata
Pawińska-Wa̧sikowska, Katarzyna
Ksia̧żek, Teofila
Sikorska-Fic, Barbara
Matysiak, Michał
Rodziewicz-Konarska, Anna
Chybicka, Alicja
Skalska-Sadowska, Jolanta
Wachowiak, Jacek
Muszyńska-Rosłan, Katarzyna
Krawczuk-Rybak, Maryna
Grabowski, Dominik
Kowalczyk, Jerzy
Zielezińska, Karolina
Urasiński, Tomasz
Tomaszewska, Renata
Szczepański, Tomasz
Karpińska-Derda, Irena
Woszczyk, Mariola
Pohorecka, Joanna
Karolczyk, Grażyna
Młynarski, Wojciech
Mycko, Katarzyna
Badowska, Wanda
Skoczeń, Szymon
Balwierz, Walentyna
author_sort Czogała, Małgorzata
collection PubMed
description Background: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018. Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (2005–2015), 33 patients were treated with chemotherapy and all-trans retinoic acid (ATRA), and in period II (2015–2018), 3 patients (high risk) received induction chemotherapy with ATRA and arsenic trioxide (ATO), and 5 patients (standard risk) received ATRA and ATO without chemotherapy. Results: Probability of 5-years overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) was 0.819 ± 0.069, 0.831 ± 0.063, and 0.961 ± 0.037, respectively, in the whole cohort. Four (11%) early deaths were observed. One patient died of severe infection in the course of disease progression. Relapse occurred in one patient, who died finally because of disease progression. All events occurred in the patients from period I. Variant APL was identified in one patient (successfully treated with chemotherapy with ATRA) and complex translocation in one patient (the only patient with relapse). Additional chromosomal aberrations were found in 26% of patients and FLT3-ITD mutation was detected in 44% of patients; none of those changes influenced clinical outcome. Conclusion: Treatment outcome in the analyzed group is similar to the results reported by other study groups. The main cause of death was coagulation disorders in the early stage of disease. Early, accurate diagnosis followed by specific treatment enables the reduction in the number of early deaths.
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spelling pubmed-71003822020-04-07 Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 Czogała, Małgorzata Pawińska-Wa̧sikowska, Katarzyna Ksia̧żek, Teofila Sikorska-Fic, Barbara Matysiak, Michał Rodziewicz-Konarska, Anna Chybicka, Alicja Skalska-Sadowska, Jolanta Wachowiak, Jacek Muszyńska-Rosłan, Katarzyna Krawczuk-Rybak, Maryna Grabowski, Dominik Kowalczyk, Jerzy Zielezińska, Karolina Urasiński, Tomasz Tomaszewska, Renata Szczepański, Tomasz Karpińska-Derda, Irena Woszczyk, Mariola Pohorecka, Joanna Karolczyk, Grażyna Młynarski, Wojciech Mycko, Katarzyna Badowska, Wanda Skoczeń, Szymon Balwierz, Walentyna Front Pediatr Pediatrics Background: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018. Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (2005–2015), 33 patients were treated with chemotherapy and all-trans retinoic acid (ATRA), and in period II (2015–2018), 3 patients (high risk) received induction chemotherapy with ATRA and arsenic trioxide (ATO), and 5 patients (standard risk) received ATRA and ATO without chemotherapy. Results: Probability of 5-years overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) was 0.819 ± 0.069, 0.831 ± 0.063, and 0.961 ± 0.037, respectively, in the whole cohort. Four (11%) early deaths were observed. One patient died of severe infection in the course of disease progression. Relapse occurred in one patient, who died finally because of disease progression. All events occurred in the patients from period I. Variant APL was identified in one patient (successfully treated with chemotherapy with ATRA) and complex translocation in one patient (the only patient with relapse). Additional chromosomal aberrations were found in 26% of patients and FLT3-ITD mutation was detected in 44% of patients; none of those changes influenced clinical outcome. Conclusion: Treatment outcome in the analyzed group is similar to the results reported by other study groups. The main cause of death was coagulation disorders in the early stage of disease. Early, accurate diagnosis followed by specific treatment enables the reduction in the number of early deaths. Frontiers Media S.A. 2020-03-20 /pmc/articles/PMC7100382/ /pubmed/32266181 http://dx.doi.org/10.3389/fped.2020.00086 Text en Copyright © 2020 Czogała, Pawińska-Wa̧sikowska, Ksia̧żek, Sikorska-Fic, Matysiak, Rodziewicz-Konarska, Chybicka, Skalska-Sadowska, Wachowiak, Muszyńska-Rosłan, Krawczuk-Rybak, Grabowski, Kowalczyk, Zielezińska, Urasiński, Tomaszewska, Szczepański, Karpińska-Derda, Woszczyk, Pohorecka, Karolczyk, Młynarski, Mycko, Badowska, Skoczeń and Balwierz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Czogała, Małgorzata
Pawińska-Wa̧sikowska, Katarzyna
Ksia̧żek, Teofila
Sikorska-Fic, Barbara
Matysiak, Michał
Rodziewicz-Konarska, Anna
Chybicka, Alicja
Skalska-Sadowska, Jolanta
Wachowiak, Jacek
Muszyńska-Rosłan, Katarzyna
Krawczuk-Rybak, Maryna
Grabowski, Dominik
Kowalczyk, Jerzy
Zielezińska, Karolina
Urasiński, Tomasz
Tomaszewska, Renata
Szczepański, Tomasz
Karpińska-Derda, Irena
Woszczyk, Mariola
Pohorecka, Joanna
Karolczyk, Grażyna
Młynarski, Wojciech
Mycko, Katarzyna
Badowska, Wanda
Skoczeń, Szymon
Balwierz, Walentyna
Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title_full Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title_fullStr Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title_full_unstemmed Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title_short Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
title_sort treatment outcome and the genetic characteristics of acute promyelocytic leukemia in children in poland from 2005 to 2018
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100382/
https://www.ncbi.nlm.nih.gov/pubmed/32266181
http://dx.doi.org/10.3389/fped.2020.00086
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