Smectic viral capsids and the aneurysm instability

The capsids of certain Archaea-infecting viruses undergo large shape changes, while maintaining their integrity against rupture by osmotic pressure. We propose that these capsids are in a smectic liquid crystalline state, with the capsid proteins assembling along spirals. We show that smectic capsid...

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Detalles Bibliográficos
Autores principales: Dharmavaram, S, Rudnick, J, Lawrence, C M, Bruinsma, R F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2018
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100389/
https://www.ncbi.nlm.nih.gov/pubmed/29578447
http://dx.doi.org/10.1088/1361-648X/aab99a
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author Dharmavaram, S
Rudnick, J
Lawrence, C M
Bruinsma, R F
author_facet Dharmavaram, S
Rudnick, J
Lawrence, C M
Bruinsma, R F
author_sort Dharmavaram, S
collection PubMed
description The capsids of certain Archaea-infecting viruses undergo large shape changes, while maintaining their integrity against rupture by osmotic pressure. We propose that these capsids are in a smectic liquid crystalline state, with the capsid proteins assembling along spirals. We show that smectic capsids are intrinsically stabilized against the formation of localized bulges with non-zero Gauss curvature while still allowing for large-scale cooperative shape transformation that involves global changes in the Gauss curvature.
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spelling pubmed-71003892020-04-03 Smectic viral capsids and the aneurysm instability Dharmavaram, S Rudnick, J Lawrence, C M Bruinsma, R F J Phys Condens Matter Paper The capsids of certain Archaea-infecting viruses undergo large shape changes, while maintaining their integrity against rupture by osmotic pressure. We propose that these capsids are in a smectic liquid crystalline state, with the capsid proteins assembling along spirals. We show that smectic capsids are intrinsically stabilized against the formation of localized bulges with non-zero Gauss curvature while still allowing for large-scale cooperative shape transformation that involves global changes in the Gauss curvature. IOP Publishing 2018-05-23 2018-04-26 /pmc/articles/PMC7100389/ /pubmed/29578447 http://dx.doi.org/10.1088/1361-648X/aab99a Text en © 2018 IOP Publishing Ltd This article is made available via the PMC Open Access Subset for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.
spellingShingle Paper
Dharmavaram, S
Rudnick, J
Lawrence, C M
Bruinsma, R F
Smectic viral capsids and the aneurysm instability
title Smectic viral capsids and the aneurysm instability
title_full Smectic viral capsids and the aneurysm instability
title_fullStr Smectic viral capsids and the aneurysm instability
title_full_unstemmed Smectic viral capsids and the aneurysm instability
title_short Smectic viral capsids and the aneurysm instability
title_sort smectic viral capsids and the aneurysm instability
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100389/
https://www.ncbi.nlm.nih.gov/pubmed/29578447
http://dx.doi.org/10.1088/1361-648X/aab99a
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AT bruinsmarf smecticviralcapsidsandtheaneurysminstability

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