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Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications
Multiple sclerosis (MS) is a chronic disease of the CNS that typically begins in late adolescence or early adulthood. It is highly variable in its expression and severity. The cause of MS is unknown, but both genetic and environmental factors have been implicated in its pathogenesis. It is known tha...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100504/ http://dx.doi.org/10.2165/00023210-199912010-00001 |
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author | Berti, Rossana Jacobson, Steven |
author_facet | Berti, Rossana Jacobson, Steven |
author_sort | Berti, Rossana |
collection | PubMed |
description | Multiple sclerosis (MS) is a chronic disease of the CNS that typically begins in late adolescence or early adulthood. It is highly variable in its expression and severity. The cause of MS is unknown, but both genetic and environmental factors have been implicated in its pathogenesis. It is known that viruses can induce chronic neurological disease, but the pathogenetic process in unclear. A viral cause for MS has been postulated, but to date no single virus has been confirmed to be associated with the disease. Although most viral candidates are no longer considered as possible aetiological agents in MS, a few are still being investigated. |
format | Online Article Text |
id | pubmed-7100504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-71005042020-03-27 Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications Berti, Rossana Jacobson, Steven CNS Drugs Leading Article Multiple sclerosis (MS) is a chronic disease of the CNS that typically begins in late adolescence or early adulthood. It is highly variable in its expression and severity. The cause of MS is unknown, but both genetic and environmental factors have been implicated in its pathogenesis. It is known that viruses can induce chronic neurological disease, but the pathogenetic process in unclear. A viral cause for MS has been postulated, but to date no single virus has been confirmed to be associated with the disease. Although most viral candidates are no longer considered as possible aetiological agents in MS, a few are still being investigated. Springer International Publishing 2012-09-14 1999 /pmc/articles/PMC7100504/ http://dx.doi.org/10.2165/00023210-199912010-00001 Text en © Adis International Limited 1999 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Leading Article Berti, Rossana Jacobson, Steven Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title | Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title_full | Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title_fullStr | Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title_full_unstemmed | Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title_short | Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications |
title_sort | role of viral infection in the aetiology of multiple sclerosis: status of current knowledge and therapeutic implications |
topic | Leading Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100504/ http://dx.doi.org/10.2165/00023210-199912010-00001 |
work_keys_str_mv | AT bertirossana roleofviralinfectionintheaetiologyofmultiplesclerosisstatusofcurrentknowledgeandtherapeuticimplications AT jacobsonsteven roleofviralinfectionintheaetiologyofmultiplesclerosisstatusofcurrentknowledgeandtherapeuticimplications |