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Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

Oncolytic herpes simplex viruses (HSVs), in clinical trials for the treatment of malignant gliomas, are assumed to be selective for tumor cells because their replication is strongly attenuated in quiescent cells, but not in cycling cells. Oncolytic selectivity is thought to occur because mutations i...

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Detalles Bibliográficos
Autores principales:	Aghi, M, Visted, T, DePinho, R A, Chiocca, E A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100519/ https://www.ncbi.nlm.nih.gov/pubmed/18345032 http://dx.doi.org/10.1038/onc.2008.53

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