A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

BACKGROUND: The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at...

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Detalles Bibliográficos
Autores principales: Earl, Julie, Galindo-Pumariño, Cristina, Encinas, Jessica, Barreto, Emma, Castillo, Maria E., Pachón, Vanessa, Ferreiro, Reyes, Rodríguez-Garrote, Mercedes, González-Martínez, Silvia, Ramon y Cajal, Teresa, Diaz, Luis Robles, Chirivella-Gonzalez, Isabel, Rodriguez, Montse, de Castro, Eva Martínez, García-Seisdedos, David, Muñoz, Gloria, Rosa, Juan Manuel Rosa, Marquez, Mirari, Malats, Nuría, Carrato, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100610/
https://www.ncbi.nlm.nih.gov/pubmed/32113160
http://dx.doi.org/10.1016/j.ebiom.2020.102675

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