A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

Aggregation of human α-synuclein (αSyn) is linked to Parkinson’s disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSyn aggregation remains unclear. Using bioinformatics, muta...

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Detalles Bibliográficos
Autores principales: Doherty, Ciaran P. A., Ulamec, Sabine M., Maya-Martinez, Roberto, Good, Sarah C., Makepeace, Jemma, Khan, G. Nasir, van Oosten-Hawle, Patricija, Radford, Sheena E., Brockwell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100612/
https://www.ncbi.nlm.nih.gov/pubmed/32157247
http://dx.doi.org/10.1038/s41594-020-0384-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100612/
https://www.ncbi.nlm.nih.gov/pubmed/32157247
http://dx.doi.org/10.1038/s41594-020-0384-x

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