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Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia (CAP). There are no available data about this disease in Tunisian intensive care patients. The objective of this study is to describe the clinical and microbiological features of pneumococcal CAP and determine the prog...

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Autores principales: Belkhouja, Khairallah, Ben Romdhane, Kaïs, Ghariani, Asma, Hammami, Afef, M’hiri, Emna, Slim-Saidi, Leila, Ben Khelil, Jalila, Besbes, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100790/
https://www.ncbi.nlm.nih.gov/pubmed/22045164
http://dx.doi.org/10.1007/s10156-011-0337-8
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author Belkhouja, Khairallah
Ben Romdhane, Kaïs
Ghariani, Asma
Hammami, Afef
M’hiri, Emna
Slim-Saidi, Leila
Ben Khelil, Jalila
Besbes, Mohamed
author_facet Belkhouja, Khairallah
Ben Romdhane, Kaïs
Ghariani, Asma
Hammami, Afef
M’hiri, Emna
Slim-Saidi, Leila
Ben Khelil, Jalila
Besbes, Mohamed
author_sort Belkhouja, Khairallah
collection PubMed
description Streptococcus pneumoniae is the most common cause of community-acquired pneumonia (CAP). There are no available data about this disease in Tunisian intensive care patients. The objective of this study is to describe the clinical and microbiological features of pneumococcal CAP and determine the prognostic factors. This is a retrospective cohort study of all pneumococcal CAP cases hospitalized in the medical intensive care unit (ICU) of Hospital A. Mami of Ariana (Tunisia) between January 1999 and August 2008. Included were 132 patients (mean age, 49.5 years; 82.6% males); 30 patients had received antimicrobial treatment before hospital admission. The mean of the Simplified Acute Physiology Score II was 32.9. All patients had an acute respiratory failure; 34 patients (25.8%) had pneumococcal bacteremic CAP. Among the isolated strains, 125 antimicrobial susceptibility tests were performed. The use of the new Clinical and Laboratory Standards Institute breakpoints for susceptibility when testing penicillin against S. pneumoniae showed that all isolated strains were susceptible to penicillin. The mortality rate was 25%. The need of mechanical ventilation at admission [odds ratio (OR), 3.4; 95% confidence interval (CI), 1.67–6.94; P = 0.001), Sepsis-related Organ Failure Assessment (SOFA) score at admission ≥4 (OR, 3.1; 95% CI, 1.56–6.13; P = 0.001), and serum creatinine at admission ≥102 μmol/l (OR, 1.8; 95% CI, 1.02–3.17; P = 0.043) were independent factors related to ICU mortality. In conclusion, pneumococcal CAP requiring hospitalization in the ICU is associated with high mortality. All isolated stains were susceptible to penicillin.
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spelling pubmed-71007902020-03-27 Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU Belkhouja, Khairallah Ben Romdhane, Kaïs Ghariani, Asma Hammami, Afef M’hiri, Emna Slim-Saidi, Leila Ben Khelil, Jalila Besbes, Mohamed J Infect Chemother Original Article Streptococcus pneumoniae is the most common cause of community-acquired pneumonia (CAP). There are no available data about this disease in Tunisian intensive care patients. The objective of this study is to describe the clinical and microbiological features of pneumococcal CAP and determine the prognostic factors. This is a retrospective cohort study of all pneumococcal CAP cases hospitalized in the medical intensive care unit (ICU) of Hospital A. Mami of Ariana (Tunisia) between January 1999 and August 2008. Included were 132 patients (mean age, 49.5 years; 82.6% males); 30 patients had received antimicrobial treatment before hospital admission. The mean of the Simplified Acute Physiology Score II was 32.9. All patients had an acute respiratory failure; 34 patients (25.8%) had pneumococcal bacteremic CAP. Among the isolated strains, 125 antimicrobial susceptibility tests were performed. The use of the new Clinical and Laboratory Standards Institute breakpoints for susceptibility when testing penicillin against S. pneumoniae showed that all isolated strains were susceptible to penicillin. The mortality rate was 25%. The need of mechanical ventilation at admission [odds ratio (OR), 3.4; 95% confidence interval (CI), 1.67–6.94; P = 0.001), Sepsis-related Organ Failure Assessment (SOFA) score at admission ≥4 (OR, 3.1; 95% CI, 1.56–6.13; P = 0.001), and serum creatinine at admission ≥102 μmol/l (OR, 1.8; 95% CI, 1.02–3.17; P = 0.043) were independent factors related to ICU mortality. In conclusion, pneumococcal CAP requiring hospitalization in the ICU is associated with high mortality. All isolated stains were susceptible to penicillin. Springer Japan 2011-11-02 2012 /pmc/articles/PMC7100790/ /pubmed/22045164 http://dx.doi.org/10.1007/s10156-011-0337-8 Text en © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Belkhouja, Khairallah
Ben Romdhane, Kaïs
Ghariani, Asma
Hammami, Afef
M’hiri, Emna
Slim-Saidi, Leila
Ben Khelil, Jalila
Besbes, Mohamed
Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title_full Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title_fullStr Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title_full_unstemmed Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title_short Severe pneumococcal community-acquired pneumonia admitted to medical Tunisian ICU
title_sort severe pneumococcal community-acquired pneumonia admitted to medical tunisian icu
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100790/
https://www.ncbi.nlm.nih.gov/pubmed/22045164
http://dx.doi.org/10.1007/s10156-011-0337-8
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