Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia

INTRODUCTION: Human parainfluenza virus type 3 (HPIV-3) causes significant morbimortality in immunocompromised patients. Outbreaks of severe pneumonitis have been previously described in this setting. MATERIALS AND METHODS: Retrospective observational study in children diagnosed with acute leukemia...

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Autores principales: Berrueco, R., Antón, A., Rives, S., Català, A., Toll, T., Ruiz, A., Camós, M., Torrebadell, M., Estella, J., Muñoz-Almagro, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100800/
https://www.ncbi.nlm.nih.gov/pubmed/23821486
http://dx.doi.org/10.1007/s15010-013-0498-8
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author Berrueco, R.
Antón, A.
Rives, S.
Català, A.
Toll, T.
Ruiz, A.
Camós, M.
Torrebadell, M.
Estella, J.
Muñoz-Almagro, C.
author_facet Berrueco, R.
Antón, A.
Rives, S.
Català, A.
Toll, T.
Ruiz, A.
Camós, M.
Torrebadell, M.
Estella, J.
Muñoz-Almagro, C.
author_sort Berrueco, R.
collection PubMed
description INTRODUCTION: Human parainfluenza virus type 3 (HPIV-3) causes significant morbimortality in immunocompromised patients. Outbreaks of severe pneumonitis have been previously described in this setting. MATERIALS AND METHODS: Retrospective observational study in children diagnosed with acute leukemia and a documented HPIV-3 infection in the context of a nosocomial outbreak occurred in a single center. RESULT: During summer 2012, an HPIV-3 infection was detected in six hospitalized children with acute leukemia. All the patients had respiratory symptoms and one of them suffered from parotitis. CONCLUSION: Early diagnoses using multiplex real-time polymerase chain reaction (PCR) let us control this outbreak. A phylogenetic analysis confirmed person-to-person transmission of a single HPIV-3 variant.
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spelling pubmed-71008002020-03-27 Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia Berrueco, R. Antón, A. Rives, S. Català, A. Toll, T. Ruiz, A. Camós, M. Torrebadell, M. Estella, J. Muñoz-Almagro, C. Infection Brief Report INTRODUCTION: Human parainfluenza virus type 3 (HPIV-3) causes significant morbimortality in immunocompromised patients. Outbreaks of severe pneumonitis have been previously described in this setting. MATERIALS AND METHODS: Retrospective observational study in children diagnosed with acute leukemia and a documented HPIV-3 infection in the context of a nosocomial outbreak occurred in a single center. RESULT: During summer 2012, an HPIV-3 infection was detected in six hospitalized children with acute leukemia. All the patients had respiratory symptoms and one of them suffered from parotitis. CONCLUSION: Early diagnoses using multiplex real-time polymerase chain reaction (PCR) let us control this outbreak. A phylogenetic analysis confirmed person-to-person transmission of a single HPIV-3 variant. Springer Berlin Heidelberg 2013-07-03 2013 /pmc/articles/PMC7100800/ /pubmed/23821486 http://dx.doi.org/10.1007/s15010-013-0498-8 Text en © Springer-Verlag Berlin Heidelberg 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Berrueco, R.
Antón, A.
Rives, S.
Català, A.
Toll, T.
Ruiz, A.
Camós, M.
Torrebadell, M.
Estella, J.
Muñoz-Almagro, C.
Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title_full Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title_fullStr Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title_full_unstemmed Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title_short Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
title_sort multiplex real-time pcr for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100800/
https://www.ncbi.nlm.nih.gov/pubmed/23821486
http://dx.doi.org/10.1007/s15010-013-0498-8
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