Cargando…

Development of a novel Ara h 2 hypoallergen with no IgE binding or anaphylactogenic activity

BACKGROUND: To date, no safe allergen-specific immunotherapy for patients with peanut allergy is available. Previous trials were associated with severe side effects. OBJECTIVE: We sought to determine the relative importance of conformational and linear IgE-binding epitopes of the major peanut allerg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tscheppe, Angelika, Palmberger, Dieter, van Rijt, Leonie, Kalic, Tanja, Mayr, Vanessa, Palladino, Chiara, Kitzmüller, Claudia, Hemmer, Wolfgang, Hafner, Christine, Bublin, Merima, van Ree, Ronald, Grabherr, Reingard, Radauer, Christian, Breiteneder, Heimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100897/ https://www.ncbi.nlm.nih.gov/pubmed/31525384 http://dx.doi.org/10.1016/j.jaci.2019.08.036

Ejemplares similares

Peanut lipids influence the response of bronchial epithelial cells to the peanut allergens Ara h 1 and Ara h 2 by decreasing barrier permeability
por: Palladino, Chiara, et al.
Publicado: (2023)

The Major Peanut Allergen Ara h 2 Produced in Nicotiana benthamiana Contains Hydroxyprolines and Is a Viable Alternative to the E. Coli Product in Allergy Diagnosis
por: Üzülmez, Öykü, et al.
Publicado: (2021)

Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells
por: Ashjaei, Kazem, et al.
Publicado: (2015)

Fish-derived low molecular weight components modify bronchial epithelial barrier properties and release of pro-inflammatory cytokines
por: Kalic, Tanja, et al.
Publicado: (2019)

Chimeras of Bet v 1 and Api g 1 reveal heterogeneous IgE responses in patients with birch pollen allergy
por: Gepp, Barbara, et al.
Publicado: (2014)

IgE cross-reactivity between the major peanut allergen Ara h 2 and the non-homologous allergens Ara h 1 and Ara h 3
por: Bublin, M, et al.
Publicado: (2013)

16 Pollen Allergens Differ From Nonallergenic Pollen Proteins by Their Lower Extent of Evolutionary Conservation
por: Radauer, Christian, et al.
Publicado: (2012)

96 Recombinant SCFV Antibodies for IGE Epitope Mapping and Detection of Parvalbumins
por: Bublin, Merima, et al.
Publicado: (2012)

Pru du 1, the Bet v 1‐homologue from almond, is a major allergen in patients with birch pollen associated almond allergy
por: Kabasser, Stefan, et al.
Publicado: (2022)

Fish Allergy Around the World—Precise Diagnosis to Facilitate Patient Management
por: Kalic, Tanja, et al.
Publicado: (2021)

Corrigendum: Fish Allergy Around the World—Precise Diagnosis to Facilitate Patient Management
por: Kalic, Tanja, et al.
Publicado: (2021)

Cross-Reactivity of Peanut Allergens
por: Bublin, Merima, et al.
Publicado: (2014)

Developing Therapies for Peanut Allergy
por: Bublin, Merima, et al.
Publicado: (2014)

Do lipids influence the allergic sensitization process?
por: Bublin, Merima, et al.
Publicado: (2014)

23 Grafting of BET V 1 Epitopes onto its Homologue API G 1 Reveals Patient-Specific IgE Recognition Profiles
por: Gepp, Barbara, et al.
Publicado: (2012)

Anaphylaxis to topical Aloe vera in a birch pollen allergic child
por: Varga, Eva-Maria, et al.
Publicado: (2014)

Newly defined allergens in the WHO/IUIS Allergen Nomenclature Database during 01/2019‐03/2021
por: Sudharson, Srinidhi, et al.
Publicado: (2021)

A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope
por: Bublin, Merima, et al.
Publicado: (2015)

Differential T-Helper Cell Polarization after Allergen-Specific Stimulation of Autologous Dendritic Cells in Polysensitized Allergic Patients
por: Ashjaei, Kazem, et al.
Publicado: (2015)

Random mutagenesis and phage display technology as a tool for identifying ige epitopes of the birch pollen allergen Bet v 1
por: Guhsl, Elisabeth Eva, et al.
Publicado: (2014)

95 Specific Recognition of the Major Birch Pollen Allergen BET V 1 Programs Dendritic Cells to Induce Either th2 or Tolerogenic Responses
por: Smole, Ursula, et al.
Publicado: (2012)

471 IgE from Birch Pollen Allergic Patients Cross-reacts with Two Distinct Bet V 1 Related Proteins in Mung Beans: VIG R 1 and Cytokinin-specific Binding Protein
por: Guhslc, Eva, et al.
Publicado: (2012)

The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals
por: Smole, Ursula, et al.
Publicado: (2015)

Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF
por: Uranowska, Karolina, et al.
Publicado: (2021)

A chondroitin sulfate proteoglycan 4-specific monoclonal antibody inhibits melanoma cell invasion in a spheroid model
por: Uranowska, Karolina, et al.
Publicado: (2021)

Advances and novel developments in molecular allergology
por: Üzülmez, Öykü, et al.
Publicado: (2020)

IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome
por: Guhsl, E E, et al.
Publicado: (2015)

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
por: Radauer, Christian, et al.
Publicado: (2008)

Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross-reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients’ sera
por: Guhsl, Eva Elisabeth, et al.
Publicado: (2013)

Ara h 6 complements Ara h 2 as an important marker for IgE reactivity to peanut
por: Hindley, J, et al.
Publicado: (2013)

Boiling and Frying Peanuts Decreases Soluble Peanut (Arachis Hypogaea) Allergens Ara h 1 and Ara h 2 But Does Not Generate Hypoallergenic Peanuts
por: Comstock, Sarah S., et al.
Publicado: (2016)

Identification of Pru du 6 as a potential marker allergen for almond allergy
por: Kabasser, Stefan, et al.
Publicado: (2020)

Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
por: Radauer, Christian, et al.
Publicado: (2011)

Tnao38, high five and Sf9—evaluation of host–virus interactions in three different insect cell lines: baculovirus production and recombinant protein expression
por: Wilde, Monika, et al.
Publicado: (2013)

Mimotopes for Api g 5, a Relevant Cross-reactive Allergen, in the Celery-Mugwort-Birch-Spice Syndrome
por: Lukschal, Anna, et al.
Publicado: (2016)

Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin
por: Kalic, Tanja, et al.
Publicado: (2019)

Identification of apple cultivars hypoallergenic for birch pollen‐allergic individuals by a multidisciplinary in vitro and in vivo approach
por: Strobl, Maria R., et al.
Publicado: (2022)

SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells
por: Palmberger, Dieter, et al.
Publicado: (2012)

Correction: SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells
por: Palmberger, Dieter, et al.
Publicado: (2012)

Development of a Dual-Vector System Utilizing MicroRNA Mimics of the Autographa californica miR-1 for an Inducible Knockdown in Insect Cells
por: Koczka, Krisztina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fqbhm2ru6pf9r2lc1e3otin9vs