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Sleep and Reproductive Health
The reproductive function of humans is regulated by several sex hormones which are secreted in synergy with the circadian timing of the body. Sleep patterns produce generic signatures that physiologically drive the synthesis, secretion, and metabolism of hormones necessary for reproduction. Sleep de...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ubiquity Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101004/ https://www.ncbi.nlm.nih.gov/pubmed/32256630 http://dx.doi.org/10.5334/jcr.190 |
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author | Lateef, Olubodun Michael Akintubosun, Michael Olawale |
author_facet | Lateef, Olubodun Michael Akintubosun, Michael Olawale |
author_sort | Lateef, Olubodun Michael |
collection | PubMed |
description | The reproductive function of humans is regulated by several sex hormones which are secreted in synergy with the circadian timing of the body. Sleep patterns produce generic signatures that physiologically drive the synthesis, secretion, and metabolism of hormones necessary for reproduction. Sleep deprivation among men and women is increasingly reported as one of the causes of infertility. In animal models, sleep disturbances impair the secretion of sexual hormones thereby leading to a decrease in testosterone level, reduced sperm motility and apoptosis of the Leydig cells in male rats. Sleep deprivation generates stressful stimuli intrinsically, due to circadian desynchrony and thereby increases the activation of the Hypothalamus-Pituitary Adrenal (HPA) axis, which, consequently, increases the production of corticosterone. The elevated level of corticosteroids results in a reduction in testosterone production. Sleep deprivation produces a commensurate effect on women by reducing the chances of fertility. Sleeplessness among female shift workers suppresses melatonin production as well as excessive HPA activation which results in early pregnancy loss, failed embryo implantation, anovulation and amenorrhea. Sleep deprivation in women has also be found to be associated with altered gonadotropin and sex steroid secretion which all together lead to female infertility. Poor quality of sleep is observed in middle-aged and older men and this also contributes to reduced testosterone concentrations. The influence of sleep disturbances post-menopausal is associated with irregular synthesis and secretion of female sex steroid hormones. |
format | Online Article Text |
id | pubmed-7101004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ubiquity Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-71010042020-03-31 Sleep and Reproductive Health Lateef, Olubodun Michael Akintubosun, Michael Olawale J Circadian Rhythms Review The reproductive function of humans is regulated by several sex hormones which are secreted in synergy with the circadian timing of the body. Sleep patterns produce generic signatures that physiologically drive the synthesis, secretion, and metabolism of hormones necessary for reproduction. Sleep deprivation among men and women is increasingly reported as one of the causes of infertility. In animal models, sleep disturbances impair the secretion of sexual hormones thereby leading to a decrease in testosterone level, reduced sperm motility and apoptosis of the Leydig cells in male rats. Sleep deprivation generates stressful stimuli intrinsically, due to circadian desynchrony and thereby increases the activation of the Hypothalamus-Pituitary Adrenal (HPA) axis, which, consequently, increases the production of corticosterone. The elevated level of corticosteroids results in a reduction in testosterone production. Sleep deprivation produces a commensurate effect on women by reducing the chances of fertility. Sleeplessness among female shift workers suppresses melatonin production as well as excessive HPA activation which results in early pregnancy loss, failed embryo implantation, anovulation and amenorrhea. Sleep deprivation in women has also be found to be associated with altered gonadotropin and sex steroid secretion which all together lead to female infertility. Poor quality of sleep is observed in middle-aged and older men and this also contributes to reduced testosterone concentrations. The influence of sleep disturbances post-menopausal is associated with irregular synthesis and secretion of female sex steroid hormones. Ubiquity Press 2020-03-23 /pmc/articles/PMC7101004/ /pubmed/32256630 http://dx.doi.org/10.5334/jcr.190 Text en Copyright: © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Lateef, Olubodun Michael Akintubosun, Michael Olawale Sleep and Reproductive Health |
title | Sleep and Reproductive Health |
title_full | Sleep and Reproductive Health |
title_fullStr | Sleep and Reproductive Health |
title_full_unstemmed | Sleep and Reproductive Health |
title_short | Sleep and Reproductive Health |
title_sort | sleep and reproductive health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101004/ https://www.ncbi.nlm.nih.gov/pubmed/32256630 http://dx.doi.org/10.5334/jcr.190 |
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