Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR(34)/L98H, TR(34)/L98H/S297T/F495I, and TR(46)/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate ob...

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Autores principales: Wu, Chi-Jung, Liu, Wei-Lun, Lai, Chih-Cheng, Chao, Chien-Ming, Ko, Wen-Chien, Wang, Hsuan-Chen, Dai, Ching-Tzu, Hsieh, Ming-I, Choi, Pui-Ching, Yang, Jia-Ling, Chen, Yee-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101115/
https://www.ncbi.nlm.nih.gov/pubmed/32186508
http://dx.doi.org/10.3201/eid2604.190840
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author Wu, Chi-Jung
Liu, Wei-Lun
Lai, Chih-Cheng
Chao, Chien-Ming
Ko, Wen-Chien
Wang, Hsuan-Chen
Dai, Ching-Tzu
Hsieh, Ming-I
Choi, Pui-Ching
Yang, Jia-Ling
Chen, Yee-Chun
author_facet Wu, Chi-Jung
Liu, Wei-Lun
Lai, Chih-Cheng
Chao, Chien-Ming
Ko, Wen-Chien
Wang, Hsuan-Chen
Dai, Ching-Tzu
Hsieh, Ming-I
Choi, Pui-Ching
Yang, Jia-Ling
Chen, Yee-Chun
author_sort Wu, Chi-Jung
collection PubMed
description In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR(34)/L98H, TR(34)/L98H/S297T/F495I, and TR(46)/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.
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spelling pubmed-71011152020-04-03 Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan Wu, Chi-Jung Liu, Wei-Lun Lai, Chih-Cheng Chao, Chien-Ming Ko, Wen-Chien Wang, Hsuan-Chen Dai, Ching-Tzu Hsieh, Ming-I Choi, Pui-Ching Yang, Jia-Ling Chen, Yee-Chun Emerg Infect Dis Research Letter In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR(34)/L98H, TR(34)/L98H/S297T/F495I, and TR(46)/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment. Centers for Disease Control and Prevention 2020-04 /pmc/articles/PMC7101115/ /pubmed/32186508 http://dx.doi.org/10.3201/eid2604.190840 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Wu, Chi-Jung
Liu, Wei-Lun
Lai, Chih-Cheng
Chao, Chien-Ming
Ko, Wen-Chien
Wang, Hsuan-Chen
Dai, Ching-Tzu
Hsieh, Ming-I
Choi, Pui-Ching
Yang, Jia-Ling
Chen, Yee-Chun
Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title_full Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title_fullStr Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title_full_unstemmed Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title_short Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
title_sort multicenter study of azole-resistant aspergillus fumigatus clinical isolates, taiwan
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101115/
https://www.ncbi.nlm.nih.gov/pubmed/32186508
http://dx.doi.org/10.3201/eid2604.190840
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