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Highly selective bile acid hydroxylation by the multifunctional bacterial P450 monooxygenase CYP107D1 (OleP)

OBJECTIVE: Regio- and stereoselective hydroxylation of lithocholic acid (LCA) using CYP107D1 (OleP), a cytochrome P450 monooxygenase from the oleandomycin synthesis pathway of Streptomyces antibioticus. RESULTS: Co-expression of CYP107D1 from S. antibioticus and the reductase/ferredoxin system PdR/P...

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Detalles Bibliográficos
Autores principales:	Grobe, Sascha, Wszołek, Agata, Brundiek, Henrike, Fekete, Melinda, Bornscheuer, Uwe T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2020
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101289/ https://www.ncbi.nlm.nih.gov/pubmed/31974648 http://dx.doi.org/10.1007/s10529-020-02813-4

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