A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/...

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Autores principales: Medeiros, Pedro Henrique Q. S., Bolick, David T., Ledwaba, Solanka E., Kolling, Glynis L., Costa, Deiziane V. S., Oriá, Reinaldo B., Lima, Aldo Ângelo M., Barry, Eileen M., Guerrant, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101394/
https://www.ncbi.nlm.nih.gov/pubmed/32257392
http://dx.doi.org/10.1038/s41541-020-0180-y
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author Medeiros, Pedro Henrique Q. S.
Bolick, David T.
Ledwaba, Solanka E.
Kolling, Glynis L.
Costa, Deiziane V. S.
Oriá, Reinaldo B.
Lima, Aldo Ângelo M.
Barry, Eileen M.
Guerrant, Richard L.
author_facet Medeiros, Pedro Henrique Q. S.
Bolick, David T.
Ledwaba, Solanka E.
Kolling, Glynis L.
Costa, Deiziane V. S.
Oriá, Reinaldo B.
Lima, Aldo Ângelo M.
Barry, Eileen M.
Guerrant, Richard L.
author_sort Medeiros, Pedro Henrique Q. S.
collection PubMed
description Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans.
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spelling pubmed-71013942020-04-06 A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice Medeiros, Pedro Henrique Q. S. Bolick, David T. Ledwaba, Solanka E. Kolling, Glynis L. Costa, Deiziane V. S. Oriá, Reinaldo B. Lima, Aldo Ângelo M. Barry, Eileen M. Guerrant, Richard L. NPJ Vaccines Brief Communication Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans. Nature Publishing Group UK 2020-03-27 /pmc/articles/PMC7101394/ /pubmed/32257392 http://dx.doi.org/10.1038/s41541-020-0180-y Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Medeiros, Pedro Henrique Q. S.
Bolick, David T.
Ledwaba, Solanka E.
Kolling, Glynis L.
Costa, Deiziane V. S.
Oriá, Reinaldo B.
Lima, Aldo Ângelo M.
Barry, Eileen M.
Guerrant, Richard L.
A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title_full A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title_fullStr A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title_full_unstemmed A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title_short A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
title_sort bivalent vaccine confers immunogenicity and protection against shigella flexneri and enterotoxigenic escherichia coli infections in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101394/
https://www.ncbi.nlm.nih.gov/pubmed/32257392
http://dx.doi.org/10.1038/s41541-020-0180-y
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