Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation that contributes to type II diabetes. Evidence suggests that the rewiring of cellular metabolism can regulate macrophage function. However, the metabolic programs that characterize adipose tissue macrophages...

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Detalles Bibliográficos
Autores principales: Sharma, Monika, Boytard, Ludovic, Hadi, Tarik, Koelwyn, Graeme, Simon, Russell, Ouimet, Mireille, Seifert, Lena, Spiro, Westley, Yan, Bo, Hutchison, Susan, Fisher, Edward A., Ramasamy, Ravichandran, Ramkhelawon, Bhama, Moore, Kathryn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101445/
https://www.ncbi.nlm.nih.gov/pubmed/32221369
http://dx.doi.org/10.1038/s41598-020-62272-9

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