Flumequine (Veterinary Medicinal Products)

FSCJ conducted a risk assessment of an antimicrobial, flumequine (CAS No. 42835-25-6), based on reports of JECFA (Joint FAO/WHO Expert Committee on Food Additives) and EMEA (European Medicines Agency) and other documents including the mechanism for liver tumor. Data used in the assessment include ph...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Food Safety Commission, Cabinet Office, Government of Japan 2020
Materias:
Risk Assessment Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101468/
https://www.ncbi.nlm.nih.gov/pubmed/32231958
http://dx.doi.org/10.14252/foodsafetyfscj.D-20-00005
Descripción
Sumario:FSCJ conducted a risk assessment of an antimicrobial, flumequine (CAS No. 42835-25-6), based on reports of JECFA (Joint FAO/WHO Expert Committee on Food Additives) and EMEA (European Medicines Agency) and other documents including the mechanism for liver tumor. Data used in the assessment include pharmacokinetics, acute toxicity, subacute toxicity, chronic toxicity/carcinogenicity, reproductive toxicity, genotoxicity, and microbiological effects. FSCJ specified the ADI of flumenquine as 0.071 mg/kg bw per day, that is the microbiological ADI calculated using the equation for VICH.

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