Monepantel (Veterinary Medicinal Products)

FSCJ conducted a risk assessment of monepantel (CAS No.887148-69-8), a parasiticide based on results from various studies. Data on pharmacokinetics (cattle) and residues (cattle) were newly submitted. Negative results were obtained in all genotoxicity and carcinogenicity studies. The no-observed-adv...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Food Safety Commission, Cabinet Office, Government of Japan 2020
Materias:
Risk Assessment Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101469/
https://www.ncbi.nlm.nih.gov/pubmed/32231956
http://dx.doi.org/10.14252/foodsafetyfscj.D-20-00001
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description FSCJ conducted a risk assessment of monepantel (CAS No.887148-69-8), a parasiticide based on results from various studies. Data on pharmacokinetics (cattle) and residues (cattle) were newly submitted. Negative results were obtained in all genotoxicity and carcinogenicity studies. The no-observed-adverse-effect level (NOAEL) obtained in all studies was 100 ppm (equivalent to 3 mg/kg bw per day for both sexes). In the 52-week chronic toxicity study in dogs, FSCJ specified an ADI for monepantel at 0.03 mg/kg bw per day based on NOAEL of 3 mg/kg bw per day, by applying a safety factor of 100.
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spelling pubmed-71014692020-03-30 Monepantel (Veterinary Medicinal Products) Food Saf (Tokyo) Risk Assessment Report FSCJ conducted a risk assessment of monepantel (CAS No.887148-69-8), a parasiticide based on results from various studies. Data on pharmacokinetics (cattle) and residues (cattle) were newly submitted. Negative results were obtained in all genotoxicity and carcinogenicity studies. The no-observed-adverse-effect level (NOAEL) obtained in all studies was 100 ppm (equivalent to 3 mg/kg bw per day for both sexes). In the 52-week chronic toxicity study in dogs, FSCJ specified an ADI for monepantel at 0.03 mg/kg bw per day based on NOAEL of 3 mg/kg bw per day, by applying a safety factor of 100. Food Safety Commission, Cabinet Office, Government of Japan 2020-03-27 /pmc/articles/PMC7101469/ /pubmed/32231956 http://dx.doi.org/10.14252/foodsafetyfscj.D-20-00001 Text en ©2020 Food Safety Commission, Cabinet Office, Government of Japan http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Risk Assessment Report
Monepantel (Veterinary Medicinal Products)
title Monepantel (Veterinary Medicinal Products)
title_full Monepantel (Veterinary Medicinal Products)
title_fullStr Monepantel (Veterinary Medicinal Products)
title_full_unstemmed Monepantel (Veterinary Medicinal Products)
title_short Monepantel (Veterinary Medicinal Products)
title_sort monepantel (veterinary medicinal products)
topic Risk Assessment Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101469/
https://www.ncbi.nlm.nih.gov/pubmed/32231956
http://dx.doi.org/10.14252/foodsafetyfscj.D-20-00001
work_keys_str_mv AT monepantelveterinarymedicinalproducts

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