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Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case

Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell ly...

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Autores principales: Sica, Antonello, Vitiello, Paola, Caccavale, Stefano, Sagnelli, Caterina, Calogero, Armando, Doraro, Concetta Anna, Pastore, Francesco, Ciardiello, Fortunato, Argenziano, Giuseppe, Reginelli, Alfonso, Cappabianca, Salvatore, Franco, Renato, Ronchi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101477/
https://www.ncbi.nlm.nih.gov/pubmed/32258414
http://dx.doi.org/10.1515/med-2020-0018
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author Sica, Antonello
Vitiello, Paola
Caccavale, Stefano
Sagnelli, Caterina
Calogero, Armando
Doraro, Concetta Anna
Pastore, Francesco
Ciardiello, Fortunato
Argenziano, Giuseppe
Reginelli, Alfonso
Cappabianca, Salvatore
Franco, Renato
Ronchi, Andrea
author_facet Sica, Antonello
Vitiello, Paola
Caccavale, Stefano
Sagnelli, Caterina
Calogero, Armando
Doraro, Concetta Anna
Pastore, Francesco
Ciardiello, Fortunato
Argenziano, Giuseppe
Reginelli, Alfonso
Cappabianca, Salvatore
Franco, Renato
Ronchi, Andrea
author_sort Sica, Antonello
collection PubMed
description Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin.
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spelling pubmed-71014772020-03-31 Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case Sica, Antonello Vitiello, Paola Caccavale, Stefano Sagnelli, Caterina Calogero, Armando Doraro, Concetta Anna Pastore, Francesco Ciardiello, Fortunato Argenziano, Giuseppe Reginelli, Alfonso Cappabianca, Salvatore Franco, Renato Ronchi, Andrea Open Med (Wars) Research Article Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin. De Gruyter 2020-03-19 /pmc/articles/PMC7101477/ /pubmed/32258414 http://dx.doi.org/10.1515/med-2020-0018 Text en © 2020 Antonello Sica et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License.
spellingShingle Research Article
Sica, Antonello
Vitiello, Paola
Caccavale, Stefano
Sagnelli, Caterina
Calogero, Armando
Doraro, Concetta Anna
Pastore, Francesco
Ciardiello, Fortunato
Argenziano, Giuseppe
Reginelli, Alfonso
Cappabianca, Salvatore
Franco, Renato
Ronchi, Andrea
Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title_full Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title_fullStr Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title_full_unstemmed Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title_short Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
title_sort primary cutaneous dlbcl non-gcb type: challenges of a rare case
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101477/
https://www.ncbi.nlm.nih.gov/pubmed/32258414
http://dx.doi.org/10.1515/med-2020-0018
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