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Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case
Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell ly...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101477/ https://www.ncbi.nlm.nih.gov/pubmed/32258414 http://dx.doi.org/10.1515/med-2020-0018 |
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author | Sica, Antonello Vitiello, Paola Caccavale, Stefano Sagnelli, Caterina Calogero, Armando Doraro, Concetta Anna Pastore, Francesco Ciardiello, Fortunato Argenziano, Giuseppe Reginelli, Alfonso Cappabianca, Salvatore Franco, Renato Ronchi, Andrea |
author_facet | Sica, Antonello Vitiello, Paola Caccavale, Stefano Sagnelli, Caterina Calogero, Armando Doraro, Concetta Anna Pastore, Francesco Ciardiello, Fortunato Argenziano, Giuseppe Reginelli, Alfonso Cappabianca, Salvatore Franco, Renato Ronchi, Andrea |
author_sort | Sica, Antonello |
collection | PubMed |
description | Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin. |
format | Online Article Text |
id | pubmed-7101477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-71014772020-03-31 Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case Sica, Antonello Vitiello, Paola Caccavale, Stefano Sagnelli, Caterina Calogero, Armando Doraro, Concetta Anna Pastore, Francesco Ciardiello, Fortunato Argenziano, Giuseppe Reginelli, Alfonso Cappabianca, Salvatore Franco, Renato Ronchi, Andrea Open Med (Wars) Research Article Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin. De Gruyter 2020-03-19 /pmc/articles/PMC7101477/ /pubmed/32258414 http://dx.doi.org/10.1515/med-2020-0018 Text en © 2020 Antonello Sica et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License. |
spellingShingle | Research Article Sica, Antonello Vitiello, Paola Caccavale, Stefano Sagnelli, Caterina Calogero, Armando Doraro, Concetta Anna Pastore, Francesco Ciardiello, Fortunato Argenziano, Giuseppe Reginelli, Alfonso Cappabianca, Salvatore Franco, Renato Ronchi, Andrea Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title | Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title_full | Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title_fullStr | Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title_full_unstemmed | Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title_short | Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case |
title_sort | primary cutaneous dlbcl non-gcb type: challenges of a rare case |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101477/ https://www.ncbi.nlm.nih.gov/pubmed/32258414 http://dx.doi.org/10.1515/med-2020-0018 |
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