Development of oncolytic virotherapy: from genetic modification to combination therapy

Oncolytic virotherapy (OVT) is a novel form of immunotherapy using natural or genetically modified viruses to selectively replicate in and kill malignant cells. Many genetically modified oncolytic viruses (OVs) with enhanced tumor targeting, antitumor efficacy, and safety have been generated, and so...

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Autores principales: Lan, Qiaoshuai, Xia, Shuai, Wang, Qian, Xu, Wei, Huang, Haiyan, Jiang, Shibo, Lu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101593/
https://www.ncbi.nlm.nih.gov/pubmed/32146606
http://dx.doi.org/10.1007/s11684-020-0750-4
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author Lan, Qiaoshuai
Xia, Shuai
Wang, Qian
Xu, Wei
Huang, Haiyan
Jiang, Shibo
Lu, Lu
author_facet Lan, Qiaoshuai
Xia, Shuai
Wang, Qian
Xu, Wei
Huang, Haiyan
Jiang, Shibo
Lu, Lu
author_sort Lan, Qiaoshuai
collection PubMed
description Oncolytic virotherapy (OVT) is a novel form of immunotherapy using natural or genetically modified viruses to selectively replicate in and kill malignant cells. Many genetically modified oncolytic viruses (OVs) with enhanced tumor targeting, antitumor efficacy, and safety have been generated, and some of which have been assessed in clinical trials. Combining OVT with other immunotherapies can remarkably enhance the antitumor efficacy. In this work, we review the use of wild-type viruses in OVT and the strategies for OV genetic modification. We also review and discuss the combinations of OVT with other immunotherapies.
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spelling pubmed-71015932020-03-31 Development of oncolytic virotherapy: from genetic modification to combination therapy Lan, Qiaoshuai Xia, Shuai Wang, Qian Xu, Wei Huang, Haiyan Jiang, Shibo Lu, Lu Front Med Review Oncolytic virotherapy (OVT) is a novel form of immunotherapy using natural or genetically modified viruses to selectively replicate in and kill malignant cells. Many genetically modified oncolytic viruses (OVs) with enhanced tumor targeting, antitumor efficacy, and safety have been generated, and some of which have been assessed in clinical trials. Combining OVT with other immunotherapies can remarkably enhance the antitumor efficacy. In this work, we review the use of wild-type viruses in OVT and the strategies for OV genetic modification. We also review and discuss the combinations of OVT with other immunotherapies. Higher Education Press 2020-03-07 2020 /pmc/articles/PMC7101593/ /pubmed/32146606 http://dx.doi.org/10.1007/s11684-020-0750-4 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Lan, Qiaoshuai
Xia, Shuai
Wang, Qian
Xu, Wei
Huang, Haiyan
Jiang, Shibo
Lu, Lu
Development of oncolytic virotherapy: from genetic modification to combination therapy
title Development of oncolytic virotherapy: from genetic modification to combination therapy
title_full Development of oncolytic virotherapy: from genetic modification to combination therapy
title_fullStr Development of oncolytic virotherapy: from genetic modification to combination therapy
title_full_unstemmed Development of oncolytic virotherapy: from genetic modification to combination therapy
title_short Development of oncolytic virotherapy: from genetic modification to combination therapy
title_sort development of oncolytic virotherapy: from genetic modification to combination therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101593/
https://www.ncbi.nlm.nih.gov/pubmed/32146606
http://dx.doi.org/10.1007/s11684-020-0750-4
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