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New insights into the importance of aminopeptidase A in hypertension

The renin-angiotensin system (RAS) plays an important role in the maintenance of normal blood pressure and the etiology of hypertension; however, minimal attention has been paid to the degradation of the effector peptide, angiotensin II (AngII). Since aminopeptidase A (APA)-deficient mice develop hy...

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Autores principales: Mizutani, Shigehiko, Ishii, Masakazu, Hattori, Akira, Nomura, Seiji, Numaguchi, Yasushi, Tsujimoto, Masafumi, Kobayshi, Hiroshi, Murohara, Toyoaki, Wright, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101674/
https://www.ncbi.nlm.nih.gov/pubmed/17990103
http://dx.doi.org/10.1007/s10741-007-9065-7
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author Mizutani, Shigehiko
Ishii, Masakazu
Hattori, Akira
Nomura, Seiji
Numaguchi, Yasushi
Tsujimoto, Masafumi
Kobayshi, Hiroshi
Murohara, Toyoaki
Wright, John W.
author_facet Mizutani, Shigehiko
Ishii, Masakazu
Hattori, Akira
Nomura, Seiji
Numaguchi, Yasushi
Tsujimoto, Masafumi
Kobayshi, Hiroshi
Murohara, Toyoaki
Wright, John W.
author_sort Mizutani, Shigehiko
collection PubMed
description The renin-angiotensin system (RAS) plays an important role in the maintenance of normal blood pressure and the etiology of hypertension; however, minimal attention has been paid to the degradation of the effector peptide, angiotensin II (AngII). Since aminopeptidase A (APA)-deficient mice develop hypertension APA appears to be an essential enzyme in the control of blood pressure via degradation of AngII. The robust hypertension seen in the spontaneously hypertensive rat (SHR) is due to activation of the RAS, and an accompanying decrease in kidney APA. Changes in APA have also been measured during the activation of the RAS in the Goldblatt hypertension model and Dahl salt-sensitive (DSS) rat. The DSS rat shows an elevation in renal APA activity at the onset of hypertension suggesting a protective role against elevations in circulating AngII, followed by decreased APA activity with advancing hypertension. Changes seen in human maternal serum APA activity during preeclampsia are similar to changes measured in renal APA in the DSS rat model. APA activity is higher than during normal pregnancy at the onset of preeclampsia, and with advancing preeclampsia (severe preeclampsia) declines below that seen during normal pregnancy. Serum APA activity is also increased during hormone replacement therapy (HRT), perhaps in reaction to elevated levels of AngII. Thus, it appears important to consider the relationship among activation of the RAS, circulating levels of AngII, and the availability of APA in hypertensive disorders.
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spelling pubmed-71016742020-03-31 New insights into the importance of aminopeptidase A in hypertension Mizutani, Shigehiko Ishii, Masakazu Hattori, Akira Nomura, Seiji Numaguchi, Yasushi Tsujimoto, Masafumi Kobayshi, Hiroshi Murohara, Toyoaki Wright, John W. Heart Fail Rev Article The renin-angiotensin system (RAS) plays an important role in the maintenance of normal blood pressure and the etiology of hypertension; however, minimal attention has been paid to the degradation of the effector peptide, angiotensin II (AngII). Since aminopeptidase A (APA)-deficient mice develop hypertension APA appears to be an essential enzyme in the control of blood pressure via degradation of AngII. The robust hypertension seen in the spontaneously hypertensive rat (SHR) is due to activation of the RAS, and an accompanying decrease in kidney APA. Changes in APA have also been measured during the activation of the RAS in the Goldblatt hypertension model and Dahl salt-sensitive (DSS) rat. The DSS rat shows an elevation in renal APA activity at the onset of hypertension suggesting a protective role against elevations in circulating AngII, followed by decreased APA activity with advancing hypertension. Changes seen in human maternal serum APA activity during preeclampsia are similar to changes measured in renal APA in the DSS rat model. APA activity is higher than during normal pregnancy at the onset of preeclampsia, and with advancing preeclampsia (severe preeclampsia) declines below that seen during normal pregnancy. Serum APA activity is also increased during hormone replacement therapy (HRT), perhaps in reaction to elevated levels of AngII. Thus, it appears important to consider the relationship among activation of the RAS, circulating levels of AngII, and the availability of APA in hypertensive disorders. Springer US 2007-11-08 2008 /pmc/articles/PMC7101674/ /pubmed/17990103 http://dx.doi.org/10.1007/s10741-007-9065-7 Text en © Springer Science+Business Media, LLC 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Mizutani, Shigehiko
Ishii, Masakazu
Hattori, Akira
Nomura, Seiji
Numaguchi, Yasushi
Tsujimoto, Masafumi
Kobayshi, Hiroshi
Murohara, Toyoaki
Wright, John W.
New insights into the importance of aminopeptidase A in hypertension
title New insights into the importance of aminopeptidase A in hypertension
title_full New insights into the importance of aminopeptidase A in hypertension
title_fullStr New insights into the importance of aminopeptidase A in hypertension
title_full_unstemmed New insights into the importance of aminopeptidase A in hypertension
title_short New insights into the importance of aminopeptidase A in hypertension
title_sort new insights into the importance of aminopeptidase a in hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101674/
https://www.ncbi.nlm.nih.gov/pubmed/17990103
http://dx.doi.org/10.1007/s10741-007-9065-7
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