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Rodent animal models: from mild to advanced stages of diabetic nephropathy

Diabetic nephropathy (DN) is a secondary complication of both type 1 and type 2 diabetes, resulting from uncontrolled high blood sugar. 30–40 % of diabetic patients develop DN associated with a poor life expectancy and end-stage renal disease, causing serious socioeconomic problems. Although an exac...

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Autores principales: Kaur, Manpreet, Bedi, Onkar, Sachdeva, Shilpi, Reddy, B. V. K. Krishna, Kumar, Puneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101706/
https://www.ncbi.nlm.nih.gov/pubmed/25149089
http://dx.doi.org/10.1007/s10787-014-0215-y
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author Kaur, Manpreet
Bedi, Onkar
Sachdeva, Shilpi
Reddy, B. V. K. Krishna
Kumar, Puneet
author_facet Kaur, Manpreet
Bedi, Onkar
Sachdeva, Shilpi
Reddy, B. V. K. Krishna
Kumar, Puneet
author_sort Kaur, Manpreet
collection PubMed
description Diabetic nephropathy (DN) is a secondary complication of both type 1 and type 2 diabetes, resulting from uncontrolled high blood sugar. 30–40 % of diabetic patients develop DN associated with a poor life expectancy and end-stage renal disease, causing serious socioeconomic problems. Although an exact pathogenesis of DN is still unknown, several factors such as hyperglycemia, hyperlipidemia, hypertension and proteinuria may contribute to the progression of renal damage in diabetic nephropathy. DN is confirmed by measuring blood urea nitrogen, serum creatinine, creatinine clearance and proteinuria. Clinical studies show that intensive control of hyperglycemia and blood pressure could successfully reduce proteinuria, which is the main sign of glomerular lesions in DN, and improve the renal prognosis in patients with DN. Diabetic rodent models have traditionally been used for doing research on pathogenesis and developing novel therapeutic strategies, but have limitations for translational research. Diabetes in animal models such as rodents are induced either spontaneously or by using chemical, surgical, genetic, or other techniques and depicts many clinical features or related phenotypes of the disease. This review discusses the merits and demerits of the models, which are used for many reasons in the research of diabetes and diabetic complications.
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spelling pubmed-71017062020-03-31 Rodent animal models: from mild to advanced stages of diabetic nephropathy Kaur, Manpreet Bedi, Onkar Sachdeva, Shilpi Reddy, B. V. K. Krishna Kumar, Puneet Inflammopharmacology Review Diabetic nephropathy (DN) is a secondary complication of both type 1 and type 2 diabetes, resulting from uncontrolled high blood sugar. 30–40 % of diabetic patients develop DN associated with a poor life expectancy and end-stage renal disease, causing serious socioeconomic problems. Although an exact pathogenesis of DN is still unknown, several factors such as hyperglycemia, hyperlipidemia, hypertension and proteinuria may contribute to the progression of renal damage in diabetic nephropathy. DN is confirmed by measuring blood urea nitrogen, serum creatinine, creatinine clearance and proteinuria. Clinical studies show that intensive control of hyperglycemia and blood pressure could successfully reduce proteinuria, which is the main sign of glomerular lesions in DN, and improve the renal prognosis in patients with DN. Diabetic rodent models have traditionally been used for doing research on pathogenesis and developing novel therapeutic strategies, but have limitations for translational research. Diabetes in animal models such as rodents are induced either spontaneously or by using chemical, surgical, genetic, or other techniques and depicts many clinical features or related phenotypes of the disease. This review discusses the merits and demerits of the models, which are used for many reasons in the research of diabetes and diabetic complications. Springer Basel 2014-08-23 2014 /pmc/articles/PMC7101706/ /pubmed/25149089 http://dx.doi.org/10.1007/s10787-014-0215-y Text en © Springer Basel 2014 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Kaur, Manpreet
Bedi, Onkar
Sachdeva, Shilpi
Reddy, B. V. K. Krishna
Kumar, Puneet
Rodent animal models: from mild to advanced stages of diabetic nephropathy
title Rodent animal models: from mild to advanced stages of diabetic nephropathy
title_full Rodent animal models: from mild to advanced stages of diabetic nephropathy
title_fullStr Rodent animal models: from mild to advanced stages of diabetic nephropathy
title_full_unstemmed Rodent animal models: from mild to advanced stages of diabetic nephropathy
title_short Rodent animal models: from mild to advanced stages of diabetic nephropathy
title_sort rodent animal models: from mild to advanced stages of diabetic nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101706/
https://www.ncbi.nlm.nih.gov/pubmed/25149089
http://dx.doi.org/10.1007/s10787-014-0215-y
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