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Medikamenteninduzierte parenchymatöse Lungenerkrankungen
Drug-induced alveolitis/pneumonitis and lung fibrosis are comparatively frequent manifestations of drug-induced damage to the respiratory system. These side effects rarely have pathognomonic features. Therefore, they are relevant differential diagnoses of naturally occurring pulmonary diseases. Side...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer-Verlag
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101887/ https://www.ncbi.nlm.nih.gov/pubmed/32288716 http://dx.doi.org/10.1007/s10405-008-0294-9 |
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author | Schreiber, J. |
author_facet | Schreiber, J. |
author_sort | Schreiber, J. |
collection | PubMed |
description | Drug-induced alveolitis/pneumonitis and lung fibrosis are comparatively frequent manifestations of drug-induced damage to the respiratory system. These side effects rarely have pathognomonic features. Therefore, they are relevant differential diagnoses of naturally occurring pulmonary diseases. Side effects of drug therapy may mimic much of the clinical-radiological-pathological pattern of interstitial lung diseases; however, precise figures on the frequency of medicamentous induction of interstitial lung disorders are lacking. The diagnostics are based mainly on verifying a compatible disease pattern, excluding differential diagnoses, and assessing the temporal relationship and the consequences of drug abstention. Reexposure is rarely indicated. Strict elimination of the responsible drugs is the most important therapeutic measure. Additional drug therapy, mostly with glucocorticosteroids, may be indicated. This article summarizes the spectrum of drug-induced disorders of the lung parenchyma. |
format | Online Article Text |
id | pubmed-7101887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-71018872020-03-31 Medikamenteninduzierte parenchymatöse Lungenerkrankungen Schreiber, J. Pneumologe (Berl) Leitthema Drug-induced alveolitis/pneumonitis and lung fibrosis are comparatively frequent manifestations of drug-induced damage to the respiratory system. These side effects rarely have pathognomonic features. Therefore, they are relevant differential diagnoses of naturally occurring pulmonary diseases. Side effects of drug therapy may mimic much of the clinical-radiological-pathological pattern of interstitial lung diseases; however, precise figures on the frequency of medicamentous induction of interstitial lung disorders are lacking. The diagnostics are based mainly on verifying a compatible disease pattern, excluding differential diagnoses, and assessing the temporal relationship and the consequences of drug abstention. Reexposure is rarely indicated. Strict elimination of the responsible drugs is the most important therapeutic measure. Additional drug therapy, mostly with glucocorticosteroids, may be indicated. This article summarizes the spectrum of drug-induced disorders of the lung parenchyma. Springer-Verlag 2009-08-01 2009 /pmc/articles/PMC7101887/ /pubmed/32288716 http://dx.doi.org/10.1007/s10405-008-0294-9 Text en © Springer Medizin Verlag 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Leitthema Schreiber, J. Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title | Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title_full | Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title_fullStr | Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title_full_unstemmed | Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title_short | Medikamenteninduzierte parenchymatöse Lungenerkrankungen |
title_sort | medikamenteninduzierte parenchymatöse lungenerkrankungen |
topic | Leitthema |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101887/ https://www.ncbi.nlm.nih.gov/pubmed/32288716 http://dx.doi.org/10.1007/s10405-008-0294-9 |
work_keys_str_mv | AT schreiberj medikamenteninduzierteparenchymatoselungenerkrankungen |