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Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term admin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101931/ https://www.ncbi.nlm.nih.gov/pubmed/22661221 http://dx.doi.org/10.1007/s10156-012-0429-0 |
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author | Hamada, Nobuyuki Imamura, Yutaka Hara, Koyu Kashiwagi, Takahito Imamura, Yoshihiro Nakazono, Yoko Chijiwa, Katsumi Watanabe, Hiroshi |
author_facet | Hamada, Nobuyuki Imamura, Yutaka Hara, Koyu Kashiwagi, Takahito Imamura, Yoshihiro Nakazono, Yoko Chijiwa, Katsumi Watanabe, Hiroshi |
author_sort | Hamada, Nobuyuki |
collection | PubMed |
description | The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs. |
format | Online Article Text |
id | pubmed-7101931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-71019312020-03-31 Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient Hamada, Nobuyuki Imamura, Yutaka Hara, Koyu Kashiwagi, Takahito Imamura, Yoshihiro Nakazono, Yoko Chijiwa, Katsumi Watanabe, Hiroshi J Infect Chemother Original Article The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs. Springer Japan 2012-06-02 2012 /pmc/articles/PMC7101931/ /pubmed/22661221 http://dx.doi.org/10.1007/s10156-012-0429-0 Text en © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Hamada, Nobuyuki Imamura, Yutaka Hara, Koyu Kashiwagi, Takahito Imamura, Yoshihiro Nakazono, Yoko Chijiwa, Katsumi Watanabe, Hiroshi Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title | Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title_full | Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title_fullStr | Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title_full_unstemmed | Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title_short | Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient |
title_sort | intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza a (h1n1) 2009 in a fatally immunocompromised patient |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101931/ https://www.ncbi.nlm.nih.gov/pubmed/22661221 http://dx.doi.org/10.1007/s10156-012-0429-0 |
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