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Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient

The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term admin...

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Autores principales: Hamada, Nobuyuki, Imamura, Yutaka, Hara, Koyu, Kashiwagi, Takahito, Imamura, Yoshihiro, Nakazono, Yoko, Chijiwa, Katsumi, Watanabe, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101931/
https://www.ncbi.nlm.nih.gov/pubmed/22661221
http://dx.doi.org/10.1007/s10156-012-0429-0
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author Hamada, Nobuyuki
Imamura, Yutaka
Hara, Koyu
Kashiwagi, Takahito
Imamura, Yoshihiro
Nakazono, Yoko
Chijiwa, Katsumi
Watanabe, Hiroshi
author_facet Hamada, Nobuyuki
Imamura, Yutaka
Hara, Koyu
Kashiwagi, Takahito
Imamura, Yoshihiro
Nakazono, Yoko
Chijiwa, Katsumi
Watanabe, Hiroshi
author_sort Hamada, Nobuyuki
collection PubMed
description The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs.
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spelling pubmed-71019312020-03-31 Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient Hamada, Nobuyuki Imamura, Yutaka Hara, Koyu Kashiwagi, Takahito Imamura, Yoshihiro Nakazono, Yoko Chijiwa, Katsumi Watanabe, Hiroshi J Infect Chemother Original Article The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs. Springer Japan 2012-06-02 2012 /pmc/articles/PMC7101931/ /pubmed/22661221 http://dx.doi.org/10.1007/s10156-012-0429-0 Text en © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Hamada, Nobuyuki
Imamura, Yutaka
Hara, Koyu
Kashiwagi, Takahito
Imamura, Yoshihiro
Nakazono, Yoko
Chijiwa, Katsumi
Watanabe, Hiroshi
Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title_full Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title_fullStr Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title_full_unstemmed Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title_short Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
title_sort intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza a (h1n1) 2009 in a fatally immunocompromised patient
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101931/
https://www.ncbi.nlm.nih.gov/pubmed/22661221
http://dx.doi.org/10.1007/s10156-012-0429-0
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